形式
powder
包装
pkg of 1 × 1 mg (860492P-1mg)
pkg of 1 × 25 mg (860492P-25mg)
pkg of 1 × 5 mg (860492P-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O
InChI
1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChI key
DUYSYHSSBDVJSM-KRWOKUGFSA-N
一般描述
鞘氨醇-1-磷酸（S1P），一种鞘脂，是重要的细胞代谢产物和动物细胞信号脂质。在酵母和植物中同样存在。鞘氨醇激酶（SPKs）催化从鞘氨醇 合成S1P，同时调节S1P水平。它是神经酰胺分解代谢的终产物，经S1P裂解酶代谢为磷酸乙醇胺和十六碳烯醛。S1P在内皮细胞中产生。
应用
鞘氨醇-1-磷酸（d18：1）用于：
- 作为高效液相色谱（HPLC）的内标品，定量血浆脂质鞘氨醇-1-磷酸（S1P）
- 评估其对自身反应性未成熟B细胞的趋化反应
- 测试其对缺氧缺糖神经元自噬和预处理的影响
生化/生理作用
鞘氨醇-1-磷酸（S1P）是信号分子和细胞内信使，对生理过程至关重要。与骨质疏松症、癌症、动脉粥样硬化和糖尿病的发病机制有关。S1P调节皮肤树突状细胞和角质形成细胞，其抗炎功能可用于治疗特应性皮炎。S1P通过与G蛋白偶联受体（GPCRS）相互作用，协调淋巴、血浆和组织中的T淋巴细胞循环。S1P是鞘氨醇-1-磷酸受体（S1P−5）的高亲和力配体。
包装
5 mL 棕色玻璃螺旋盖小瓶 (860492P-1 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860492P-25 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860492P-5 mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development
Donovan EE, et al.
European Journal of Immunology, 40(3), 688-698 (2010)
Liao-Liao Hu et al.
Cells, 8(11) (2019-11-17)
CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the
Effects of apolipoprotein M in uremic atherosclerosis
Bosteen MH, et al.
Atherosclerosis, 265(3), 93-101 (2017)
Collin Tran et al.
Journal of neurochemistry, e14917-e14917 (2019-11-20)
Sphingosine 1-phosphate (S1P) is an essential lipid metabolite that signals through a family of five G protein-coupled receptors, S1PR1-S1PR5, to regulate cell physiology. The multiple sclerosis drug Fingolimod (FTY720) is a potent S1P receptor agonist that causes peripheral lymphopenia. Recent
Suwon Jeon et al.
Journal of lipid research, 61(1), 20-32 (2019-11-07)
Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. Because S1P induces differentiation of keratinocytes, we examined whether modulation of
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