C195
(2S,3R,4S)-α-(羧基环丙基)甘氨酸
solid
别名:
(2S,1′R,2′S)-2-(2-羧基环丙基)甘氨酸, (2S,3R,4S)-CCG, L-CCG-IV
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关于此项目
经验公式（希尔记法）:
C6H9NO4
化学文摘社编号:
分子量:
159.14
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
InChI
1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
SMILES string
[H][C@]1(C[C@@H]1C(O)=O)[C@H](N)C(O)=O
InChI key
GZOVEPYOCJWRFC-UZBSEBFBSA-N
form
solid
optical activity
[α]/D +69.5°, c = 0.4 in H2O(lit.)
reaction suitability
reaction type: solution phase peptide synthesis
color
off-white
solubility
H2O: soluble
application(s)
peptide synthesis
Biochem/physiol Actions
强效 NMDA 受体激动剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Jennifer A Feeley Kearney et al.
Experimental neurology, 184 Suppl 1, S30-S36 (2003-11-05)
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled excitatory amino acid (glutamate) receptors and are abundantly expressed in basal ganglia nuclei. We used behavioral, regional glucose uptake metabolic mapping, and FOS protein expression to examine the effects of stimulating striatal and subthalamic
Timo Kirschstein et al.
Neuropharmacology, 47(2), 157-162 (2004-06-30)
Specific agonists of metabotropic glutamate receptors (mGluRs) provide powerful tools to discriminate afferent fibers originating from different presynaptic neurons. The group II mGluR agonists L-CCG-I ((2S,1'S,2'S)-2-(2-carboxycyclopropyl)glycine) and DCG-IV ((2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine) are commonly used to distinguish between mossy fiber and associational-commissural (A/C)
Cynthia Levinthal et al.
Pharmacology, 83(2), 88-94 (2008-12-10)
Protons act as neuromodulators and produce significant effects on synaptic transmission. The molecular basis of neuromodulation by extracellular protons is partially explained by their effects on certain neurotransmitter receptors and ion channels. The metabotropic glutamate receptors (mGluRs) are a family
Ke-Zhong Shen et al.
The Journal of physiology, 553(Pt 2), 489-496 (2003-09-23)
Patch pipettes were used to record currents in whole-cell configuration to study the effects of group II metabotropic glutamate receptor (mGluR) stimulation on synaptic transmission in slices of rat subthalamic nucleus. Evoked glutamatergic excitatory postsynaptic currents (EPSCs) were reversibly reduced
Maria Smiałowska et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32(6), 1242-1250 (2006-11-30)
Earlier studies conducted by our group and by other authors indicated that metabotropic glutamatergic receptor (mGluR) ligands might have anxiolytic activity and that amygdalar neuropeptide Y (NPY) neurons were engaged in that effect. Apart from the amygdala, the hippocampus, another
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