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Merck
CN
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文件

914827

Sigma-Aldrich

N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride

≥98%

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别名:
(S)-Amino-6-((prop-2-ynyloxy)carbonylamino)hexanoic acid hydrochloride, Clickable amino acid for bioconjugation, H-L-Lys(Poc)-OH HCl, Lysine-alkyne, Plk, Propargyl-derivatized lysize, UAA crosslinker
经验公式（希尔记法）:
C10H16N2O4 · xHCl
CAS号:
1428330-91-9
分子量:
228.25 (free base basis)
UNSPSC代码:
12352200

检测方案

≥98%

形式

powder

储存温度

2-8°C

应用

N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride is a clickable amino acid derivative for site-specific incorporation into recombinant proteins or synthesis of chemical probes and tools for biological applications. This non-canonical lysine possesses an alkyne for bioorthogonal reaction with azides.

其他说明

Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody-Antigen Binding on Live Cells Quick View Other Sources

PEGylated polylysine derived copolymers with reduction-responsive side chains for anticancer drug delivery

Construction of bacterial cells with an active transport system for unnatural amino acids

Semisynthesis of an Active Enzyme by Quantitative Click Ligation

Combined Use of Unnatural Amino Acids Enables Dual-Color Super-Resolution Imaging of Proteins via Click Chemistry

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Yiming Li et al.
Organic & biomolecular chemistry, 11(16), 2624-2629 (2013-03-02)
Three alkyne-containing pyrrolysine derivatives were synthesized and genetically encoded into proteins by a mutant PylRS-tRNA pair with high efficiencies. With these alkyne handles, site-specific dual labeling of proteins can be achieved via a bioorthogonal thiol-yne ligation reaction.
Ivana Nikić et al.
Angewandte Chemie (International ed. in English), 53(8), 2245-2249 (2014-01-30)
The growing demands of advanced fluorescence and super-resolution microscopy benefit from the development of small and highly photostable fluorescent probes. Techniques developed to expand the genetic code permit the residue-specific encoding of unnatural amino acids (UAAs) armed with novel clickable
Claudio Zambaldo et al.
Journal of the American Chemical Society, 139(34), 11646-11649 (2017-08-16)
Nisin is a complex lanthipeptide that has broad spectrum antibacterial activity. In efforts to broaden the structural diversity of this ribosomally synthesized lantibiotic, we now report the recombinant expression of Nisin variants that incorporate noncanonical amino acids (ncAAs) at discrete
K W Swiderska et al.
Bioorganic & medicinal chemistry, 25(14), 3685-3693 (2017-05-20)
Recent advances in site-specific protein modification include the increasingly popular incorporation of unnatural amino acid(s) using amber codon, a method developed by Schultz and coworkers. In this study, we employ this technique to introduce propargyllysine (PrK) in human fibroblast growth
Tatjana Schneider et al.
Angewandte Chemie (International ed. in English), 53(47), 12925-12929 (2014-09-10)
Ubiquitylation is a complex posttranslational protein modification and deregulation of this pathway has been associated with different human disorders. Ubiquitylation comes in different flavors: Besides mono-ubiquitylation, ubiquitin chains of various topologies are formed on substrate proteins. The fate of ubiquitylated
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