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方案
≥95%
表单
liquid
官能团
fluoro
InChI
1S/C9H11FO/c1-7(2)11-9-5-3-4-8(10)6-9/h3-7H,1-2H3
InChI key
INDGWZOOYLDIPO-UHFFFAOYSA-N
应用
1-Fluoro-3-isopropoxybenzene is a versatile building block for the preparation of ligands such as EPhos, piperidinemethanols, and functionalized xanthones.
其他说明
- Mechanistic insight leads to a ligand which facilitates the palladium-catalyzed formation of 2-(hetero)arylaminooxazoles and 4-(hetero)arylaminothiazoles
- Diastereoselective Syntheses of (3R*,4R*)- and (3R*,4S*)-4-Aryl-3-methyl-4-piperidinemethanol and Fluoro Analogues
- Solvent-controlled leaving-group selectivity in aromatic nucleophilic substitution
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Sébastien Schmitt et al.
The Journal of organic chemistry, 78(3), 1222-1229 (2013-01-10)
Two concise and high-yielding diastereoselective syntheses of 4-aryl-3-methyl-4-piperidinemethanols were realized from 1,3-dimethyl-4-piperidinone. The key reactions to control the C3-C4 relative stereochemistry were the alkoxymethylation of a metalloenamine generated from 4-aryl-3-methyl-1,2,3,6-tetrahydropyridine that afforded the (3R*,4S*)-form and the nucleophilic substitution of a
Mechanistic Insight Leads to a Ligand Which Facilitates the Palladium?Catalyzed Formation of 2?(Hetero) Arylaminooxazoles and 4?(Hetero) Arylaminothiazoles.
Olsen E P, et al.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 129(35), 10705-10708 (2017)
Lukas Hintermann et al.
Organic letters, 10(21), 4859-4862 (2008-10-10)
A solvent-controlled inversion of leaving group ability allows selective access to either of two internal substitution products in S(N)Ar reactions of substrates with competing leaving groups. Application of this principle in a selective synthesis of the highly functionalized xanthone core
Diastereoselective Syntheses of (3 R*, 4 R*)-and (3 R*, 4 S*)-4-Aryl-3-methyl-4-piperidinemethanol and Fluoro Analogues.
Schmitt S, et al.
The Journal of Organic Chemistry, 78(3), 1222-1229 (2013)
Esben P K Olsen et al.
Angewandte Chemie (International ed. in English), 56(35), 10569-10572 (2017-06-13)
By using mechanistic insight, a new ligand (EPhos) for the palladium-catalyzed C-N cross-coupling between primary amines and aryl halides has been developed. Employing an isopropoxy group at the C3-position favors the C-bound isomer of the ligand-supported palladium(II) complexes and leads
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