852767
5-硝基脲嘧啶
98%
别名:
2,4-二羟基-5-硝基嘧啶
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关于此项目
经验公式（希尔记法）:
C4H3N3O4
化学文摘社编号:
分子量:
157.08
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
210-250-4
Beilstein/REAXYS Number:
10410
MDL number:
InChI key
TUARVSWVPPVUGS-UHFFFAOYSA-N
InChI
1S/C4H3N3O4/c8-3-2(7(10)11)1-5-4(9)6-3/h1H,(H2,5,6,8,9)
SMILES string
[O-][N+](=O)C1=CNC(=O)NC1=O
assay
98%
form
powder
mp
>300 °C (lit.)
Application
酶抑制剂。
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
J A Smiley et al.
Analytical biochemistry, 266(1), 85-92 (1999-01-15)
A few organisms, notably some fungi, have the ability to metabolize thymidine to uracil, thus conserving the pyrimidine ring for subsequent metabolic use. Neurospora crassa possesses this pathway, termed the thymidine salvage pathway, and can utilize thymidine as a total
S G Stepan'ian et al.
Biofizika, 34(5), 753-757 (1989-09-01)
The high-resolution IR-spectra of 5-nitrouracil and 5-bromouracil isolated in Ar matrices at 11 K were obtained for the first time. The conformational structure of uracil 5-substituents--thymine, 5-bromouracil, 5-nitrouracil--is calculated by the molecular mechanics and quantum--chemical MINDO/3 methods. The possibility of
T Kita et al.
Biological & pharmaceutical bulletin, 24(7), 860-862 (2001-07-18)
Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/ platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (9) was found to be a more potent inhibitor than the classical inhibitor, 5-nitrouracil (1). Lineweaver-Burk plot
X Gu et al.
Nucleic acids research, 24(6), 1059-1064 (1996-03-15)
tRNA in which uracil is completely replaced by 5-nitro-uracil was prepared by substituting 5-nitro-UTP for UTP in an in vitro transcription reaction. The rationale was that the 5-nitro substituent activates the 6-carbon of the Ura heterocycle towards nucleophiles, and hence
P J Nykänen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 96(9), 768-772 (1988-09-01)
The degradation of 3H-thymidine under various cell culture conditions was analysed. It was found that a half of 3H-thymidine was degraded to 3H-thymine during 24 hours in PHA stimulation of blood lymphocytes. A control culture in which PHA was not
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