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Merck
CN

794384

Sigma-Aldrich

胆固醇-TEG 叠氮化物

别名:

3-(13-azido-5,8,11-trioxa-2-azatridecanoate) cholesterol

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About This Item

经验公式(希尔记法):
C36H62N4O5
分子量:
630.90
UNSPSC代码:
12352125
PubChem化学物质编号:
NACRES:
NA.22

形式

solid

质量水平

储存温度

−20°C

SMILES字符串

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCOCCOCCOCCN=[N+]=[N-])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

InChI

1S/C36H62N4O5/c1-26(2)7-6-8-27(3)31-11-12-32-30-10-9-28-25-29(13-15-35(28,4)33(30)14-16-36(31,32)5)45-34(41)38-17-19-42-21-23-44-24-22-43-20-18-39-40-37/h9,26-27,29-33H,6-8,10-25H2,1-5H3,(H,38,41)/t27-,29+,30+,31-,32+,33+,35+,36-/m1/s1

InChI key

POWZASPNLQFLJO-MKQVXYPISA-N

相关类别

应用

胆固醇-TEG 叠氮化物是一种含叠氮化物胆固醇衍生物,可用作铜(I)催化叠氮-炔环加成(CuAAC)反应试剂以引入胆固醇标签。据报道,它也用于构建新型大麻素-siRNA偶联物。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Natalia Kleczewska et al.
Chemical science, 12(30), 10242-10251 (2021-08-12)
Targeting cap-dependent translation initiation is one of the experimental approaches that could lead to the development of novel anti-cancer therapies. Synthetic dinucleoside 5',5'-triphosphates cap analogs are potent antagonists of eukaryotic translation initiation factor 4E (eIF4E) in vitro and could counteract
Julian Willibald et al.
Journal of the American Chemical Society, 134(30), 12330-12333 (2012-07-21)
Click chemistry of alkyne-modified RNA with different receptor ligand azides was used to prepare 3'-folate, 3'-cholesterol, and, as a new entity, 3'-anandamide-modified RNA in high yields and excellent purity. The anandamide-modified RNA shows surprisingly high transfection properties and enables the

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