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Merck
CN

762024

Sigma-Aldrich

N-[2-[2-[2-(2-叠氮乙氧基)乙氧基]乙氧基]乙基]生物素胺

别名:

N- [2- [2- [2-(2-叠氮基乙氧基)乙氧基]乙氧基]乙基]六氢-2-氧代-(3aS,4S,6aR)-1H-噻吩并[3,4-d]咪唑-4-戊酰胺, 生物素-PEG3-叠氮化物

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About This Item

经验公式(希尔记法):
C18H32N6O5S
分子量:
444.55
MDL编号:
UNSPSC代码:
12352125
PubChem化学物质编号:
NACRES:
NA.22

表单

solid

质量水平

反应适用性

reaction type: click chemistry

储存温度

−20°C

SMILES字符串

O=C1N[C@](CS[C@H]2CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)([H])[C@]2([H])N1

InChI

1S/C18H32N6O5S/c19-24-21-6-8-28-10-12-29-11-9-27-7-5-20-16(25)4-2-1-3-15-17-14(13-30-15)22-18(26)23-17/h14-15,17H,1-13H2,(H,20,25)(H2,22,23,26)/t14-,15-,17-/m1/s1

InChI key

ZWFOOMQCYIGZBE-BFYDXBDKSA-N

应用

在与荧光链霉抗生物素蛋白缀合物一起温育后,叠氮化物-PEG3-生物素缀合物已经用荧光显微镜通过点击化学检测细胞炔烃胆固醇类似物。它还被用于制备新型多功能二苯甲酮接头,可用于 pull-down 试验、光亲和标记和双击装订技术。
生物素化试剂,使用铜催化的 1,3 偶极环加成点击化学或无环点击化学与环辛炔衍生物,用于标记含炔烃的分子或生物分子。叠氮基团与炔烃反应形成稳定的三唑键,促进生物素进入您感兴趣的炔烃改性体系。该反应是生物正交的,换言之与生物系统相容,因为它的组分不与生物环境反应。

凭借Synple 全自动合成平台(SYNPLE-SC002)自动标记您的生物素

相关产品

产品编号
说明
价格

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Woo CM, et al.
Analytical and Bioanalytical Chemistry, 409(2), 579-588 (2017)
Chapter Five-Mapping Lysine Acetyltransferase?Ligand Interactions by Activity-Based Capture
Montgomery DC & Meier JL
Methods in Enzymology, 574, 105-123 (2016)
A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization.
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Journal of Lipid Research, 55(3), 583-591 (2014)
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The Journal of organic chemistry, 85(3), 1691-1697 (2019-12-26)
Methylglyoxal (MGO) is a reactive dicarbonyl metabolite that modifies histones in vivo and induces changes in chromatin structure and function. Here we report the synthesis and application of a chemical probe for investigating MGO-glycation. A two-step synthesis of a Cu-click

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