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739979

Resomer^® RG 858 S，聚(D,L-丙交酯-共-乙交酯)

Name: Resomer<SUP>®</SUP> RG 858 S，聚(<SC>D,L</SC>-丙交酯-<I>共</I>-乙交酯)
Brand: ALDRICH

ester terminated, lactide:glycolide 85:15, M_w 190,000-240,000

别名:

PLGA

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About This Item

线性分子式:

[C₃H₄O₂]_x[C₂H₂O₂]_y

CAS号:

26780-50-7

UNSPSC代码:

12162002

NACRES:

NA.23

质量水平

100

形式

amorphous

投料比

lactide:glycolide 85:15

分子量

M_w 190,000-240,000

降解时间线

<9 months

粘度

1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

储存温度

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

一般描述

RESOMER^®聚合物是生物可吸收的脂肪族聚酯，它由一系列不同比例的丙交酯和乙交酯单体、PLA立体化学和端基官能化组成。这些丙交酯和乙交酯的生物可降解均聚物和共聚物具有多种特性，其范围从降解时间长的刚性硬质半晶体材料到降解速率更快、更软的无定形材料。

应用

Electrospun Resomer^® X 206 S与来自甘蔗渣的纤维素混合，可用作组织工程中的支架。

控制释放

特点和优势

生物活性剂的控制释放、缝合线和生物可吸收性可植入装置。

法律信息

Evonik产品

RESOMER is a registered trademark of Evonik Rohm GmbH

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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RESOMER??Biodegradeable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Mader K

Material Matters, 6(3), 62-62 (2011)

Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits.

Teresa Musumeci et al.

International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)

Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging

Reduced postoperative chronic pain after tension-free inguinal hernia repair using absorbable sutures: a single-blind randomized clinical trial.

Igor Jeroukhimov et al.

Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)

Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures

Pediatric anophthalmic sockets and orbital implants: outcomes with polymer-coated implants.

Maria Kirzhner et al.

Ophthalmology, 120(6), 1300-1304 (2013-02-13)

To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and

Effect of water on exenatide acylation in poly(lactide-co-glycolide) microspheres.

Rongcai Liang et al.

International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)

Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative

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RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

聚甘油癸二酸酯在组织工程和再生医学的应用

商业生物材料已停滞不前超过30年的时间，因为很少有材料能够成功地从实验台过渡到临床使用。合成型脂族聚酯因其悠久的历史和获得美国食品药品监督管理局（FDA）批准的记录，一直在可吸收生物材料领域占据主导地位。

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Resomer® RG 858 S，聚(D,L-丙交酯-共-乙交酯)

ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000