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915408

Sigma-Aldrich

NanoFabTx™ PEGylated nanoparticle formulation screening kit

别名:

NanoFabTx™ reagent kit, Nanoparticle synthesis kit, PEGylated nanoformulations

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1 KIT
CN¥4,429.37

CN¥4,429.37

预计发货时间June 05, 2025详情

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1 KIT
CN¥4,429.37

About This Item

UNSPSC代码:
12161503
NACRES:
NA.23

CN¥4,429.37

预计发货时间June 05, 2025详情

购买套餐
获取大包装报价

描述

Kit components :
PEGPLGA-50L (912808-500mg)
PEGPLGA-75L (913049-500mg)
PEGPLA-L (913308-500mg)
PEGPCL-H (912549-500mg)
Stabilizer - P (913448-10g)
Materials screening kit, for synthesis of PEGylated polymeric nanoparticles

质量水平

100

应用

advanced drug delivery

储存温度

2-8°C

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917796918881918075
NanoFabTx™ PEGylated nanoparticle formulation screening kit

915408

NanoFabTx™ PEGylated nanoparticle formulation screening kit

NanoFabTx™ PEG-PLGA drug formulation screening kit for synthesis of PEGylated nanoparticles

917796

NanoFabTx™ PEG-PLGA drug formulation screening kit

NanoFabTx™ PEG-PCL drug formulation screening kit for synthesis of PEGylated nanoparticles

918881

NanoFabTx™ PEG-PCL drug formulation screening kit

NanoFabTx™ PLA-nano for synthesis of 100 and 200 nm particles

918075

NanoFabTx™ PLA-nano

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

description

Kit components :
PEGPLGA-50L (912808-500mg)
PEGPLGA-75L (913049-500mg)
PEGPLA-L (913308-500mg)
PEGPCL-H (912549-500mg)
Stabilizer - P (913448-10g)

description

Drug loading screening kit, for synthesis of PEGylated PLGA nanoparticles, Kit components :
PEGPLGA-50L(912808-500mg)
PEGPLGA-75L(913049-500mg)
PEGPLGA-50H (915955-500mg)
PEGPLGA-75H (915718-500mg)
Stabilizer-Nano (907766-5g)

description

Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles, Kit components :
PEGPCL-L(915203-500mg)
PEGPCL-H(912549-500mg)
PEGPCL-UH (917788-500mg)
Stabilizer-Nano (907766-5g)

description

-

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

一般描述

NanoFabTx™ PEGylated nanoparticle formulation screening kit contains optimized reagents and protocols for nanoprecipiation and microfluidic-based synthesis of polymer nanoparticles. The kit provides rationally selected PEGylated PLGA, PLA, and PCL polymers, which are widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules. This reagent kit can be combined with the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 911593) for microfluidic synthesis of polymer nanoparticles 60 to 100 nm in size.

应用

NanoFabTx™ PEGylated nanoparticle formulation screening kit is designed for the synthesis of specifically sized, hydrophobic drug encapsulated biodegradable PEGylated polymer nanoparticles. Our specially designed PEGylated polymers result in nanoparticles with a PEG surface coating that reduces protein absorption and prolongs circulation time, leading to slow and sustained release of the encapsulated drug. The NanoFabTx™ PEGylated nanoparticle formulation screening kit enables nanoparticle optimization by selection of the right polymer to achieve the desired nanoparticle size, drug encapsulation, release kinetics, and stability in systemic circulation. This kit provides reagents and protocols for nanoprecipitation and microfluidics to synthesize 60 nm to 100 nm nanoparticles.

特点和优势

  • Provides step-by-step protocols, both for standard extrusion or microfluidic-based synthesis, developed and tested by our formulation scientists
  • Microfluidic formulation development for enhancing drug bioavailability
  • Flexible synthesis tool to create uniform and reproducible nanoparticles
  • Optimized to make nanoparticles from 60-100 nm
  • Includes 4 different PEGylated polymers to identify the optimal material

法律信息

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

相关产品

产品编号
说明
价格

911593

NanoFabTx™ 微流体 - 纳米, device kit for synthesis of 100-200 nm nanoparticles and liposomes

911860

NanoFabTx™ microfluidic - micro, device kit for synthesis of 1-5 μm particles

911879

NanoFabTx™ microfluidic - micro, device kit for synthesis of 10-30 μm particles

909637

NanoFabTx™ PLGA-nano, for synthesis of 100 and 200 nm particles

912212

NanoFabTx™ PLGA-micro, for synthesis of 10-30 um particles

912220

NanoFabTx™ PLGA-micro, for synthesis of 1-5 μm particles

920436

NanoFabTx™ PEG-PLA drug formulation screening kit, for synthesis of PEGylated nanoparticles

915408

NanoFabTx™ PEGylated nanoparticle formulation screening kit

917796

NanoFabTx™ PEG-PLGA drug formulation screening kit, for synthesis of PEGylated nanoparticles

918881

NanoFabTx™ PEG-PCL drug formulation screening kit, for synthesis of PEGylated nanoparticles

918075

NanoFabTx™ PLA-nano, for synthesis of 100 and 200 nm particles

储存分类代码

12 - Non Combustible Liquids

法规信息

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    S Freiberg et al.
    International journal of pharmaceutics, 282(1-2), 1-18 (2004-09-01)
    Polymer microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release
    C Thomasin et al.
    Journal of pharmaceutical sciences, 87(3), 269-275 (1998-04-02)
    Phase separation (frequently called coacervation) of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) is a classical method for drug microencapsulation. Here, attempts have been made to describe this process in the light of thermodynamics. Different PLA/PLGAs were dissolved in either dichloromethane or
    Robert F Pagels et al.
    Journal of controlled release : official journal of the Controlled Release Society, 219, 519-535 (2015-09-12)
    Biologically derived therapeutics, or biologics, are the most rapidly growing segment of the pharmaceutical marketplace. However, there are still unmet needs in improving the delivery of biologics. Injectable polymeric nanoparticles and microparticles capable of releasing proteins and peptides over time
    Byung Kook Lee et al.
    Advanced drug delivery reviews, 107, 176-191 (2016-06-06)
    Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are
    Nazila Kamaly et al.
    Chemical Society reviews, 41(7), 2971-3010 (2012-03-06)
    Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery
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