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Merck
CN

730998

tBuBrettPhos

97%, solid

别名:

t -BuBrett-Phos, t-Bu Brett Phos, tertButylBrettPhos, t -BuBrett Phos, t-BuBrettPhos, [3,6-二甲氧基-2′,4′,6′-三(1-甲基乙基)[1,1′-联苯基]-2-基]双(1,1-二甲基乙基)膦, tert-ButylBrettPhos

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关于此项目

经验公式(希尔记法):
C31H49O2P
化学文摘社编号:
分子量:
484.69
UNSPSC Code:
12352112
PubChem Substance ID:
NACRES:
NA.22
MDL number:
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产品名称

tBuBrettPhos, 97%

SMILES string

COc1ccc(OC)c(c1P(C(C)(C)C)C(C)(C)C)-c2c(cc(cc2C(C)C)C(C)C)C(C)C

InChI

1S/C31H49O2P/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12/h15-21H,1-14H3

InChI key

REWLCYPYZCHYSS-UHFFFAOYSA-N

assay

97%

form

solid

reaction suitability

reaction type: Cross Couplings
reagent type: ligand
reaction type: Arylations

reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction

reagent type: ligand
reaction type: C-X Bond Formation

reagent type: ligand
reaction type: Fluorinations

mp

166-170 °C

functional group

phosphine

Quality Level

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Application

常见应用
  • Buchwald-Hartwig 胺化和 C-O 偶联
  • Suzuki,Negishi,Stille,Hiyama,Sonogashira 交叉耦合
  • α-芳基化反应


新应用:
  • 芳基和乙烯基三氟酸盐转化为溴化物和氯化物
  • 芳基三氟酸盐转化为芳基氟化物
  • O -乙酰氢肟酸乙酯的芳基化
  • 芳基氯化物和磺酸盐转化为硝基芳烃

Features and Benefits

  • 白色结晶固体
  • 空气和水分稳定
  • 热稳定
  • 高效
  • 宽官能团容差
  • 极佳的选择性和转化率

General description

tBuBrettPhos是由 Buchwald 研究组开发的二烷基二芳基膦配体。它可以更高效地促进交叉偶联反应,并具有优于其它催化系统的反应活性。

tBuBrettPhos是一种膦配体,广泛应用于钯催化交叉偶联反应。

Legal Information

使用受美国专利 7858784约束

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Pd-Catalyzed O-Arylation of Ethyl Acetohydroximate: Synthesis of O-Arylhydroxylamines and Substituted Benzofuran
Maimone TJ, et al.
Journal of the American Chemical Society, 132, 9990-9990 (2010)
Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics.
Fors BP, et al.
Journal of the American Chemical Society, 131, 12898-12898 (2009)
Transition-metal-catalyzed cross-couplings through carbene migratory insertion
Xia Y, et al.
Chemical Reviews, 117(23), 13810-13889 (2017)
Formation of ArF from LPdAr (F): Catalytic conversion of aryl triflates to aryl fluorides.
Watson DA, et al.
Science, 325, 1661-1661 (2009)
Xiaoqiang Shen et al.
Journal of the American Chemical Society, 132(40), 14076-14078 (2010-09-23)
The palladium-catalyzed conversion of aryl and vinyl triflates to aryl and vinyl halides (bromides and chlorides) has been developed using dialkylbiaryl phosphine ligands. A variety of aryl, heteroaryl, and vinyl halides can be prepared via this method in good to

相关内容

The Catalexis platform enhances catalysis by digitally optimizing catalyst selection to identify the most effective phosphine ligands for cross-coupling reactions.

Explore reliable, premium grade catalysis materials for your pharma or industrial project. Specialty chemicals and formulations are available in bulk quantities and volumes from a few grams to multi-metric tons with complete documentation to simplify your leap from development to commercialization.

Catalexis平台通过数字化优化催化剂筛选,识别出交叉偶联反应最有效的膦配体,从而增强催化作用。

Phosphine Ligand Application Guide

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