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719900

Sigma-Aldrich

Resomer® RG 504 H，聚（D,L-丙交酯-co-乙交酯）

acid terminated, lactide:glycolide 50:50, Mw 38,000-54,000

别名:

RESOMER® RG 504 H, PLGA

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
26780-50-7
MDL编号:
MFCD00131930
UNSPSC代码:
12162002
NACRES:
NA.23

质量水平

200

表单

amorphous

投料比

lactide:glycolide 50:50

分子量

Mw 38,000-54,000

降解时间线

<3 months

粘度

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

转变温度

Tg 46-50 °C

储存温度

2-8°C

SMILES字符串

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

相关类别

应用

Resomer® RG 504 H， 聚（D, L-丙交酯-co-乙交酯）可用于制造一种可生物降解的 止血装置，用于安全和局部控制释放凝血酶， 促进局部血栓形成。

它也可用于制备：包封氧化铜的聚合物纳米球，形成刺激响应的多功能纳米载体。

法律信息

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV5944
BCCH5449
BCCG3293
BCCD7787
BCCC6288

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Nanomaterials (Basel, Switzerland), 9(9) (2019-09-05)
There is a pressing clinical need for advanced colon-specific local drug delivery systems that can provide major advantages in treating diseases associated with the colon, such as inflammatory bowel disease (IBD) and colon cancer. A precise colon targeted drug delivery
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An in situ forming gel (ISFG) of buprenorphine (BP) was prepared using PLGA-PEG-PLGA (triblock) and N‑methyl‑2‑pyrrolidone as solvent for decreasing the initial burst release. Supercritical CO2 method was used for ring opening polymerization of triblock. The optimum formulation of ISFG
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The objective of this study was to assess the effect of absorbable or nonabsorbable sutures in bioenhanced anterior cruciate ligament (ACL) repair in a skeletally immature pig model on suture tunnel and growth plate healing and biomechanical outcomes. Sixteen female
Kyle E Broaders et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(14), 5497-5502 (2009-03-27)
Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that
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Nature biotechnology, 30(12), 1217-1224 (2012-11-20)
Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce T-cell tolerance have failed. Building on previous strategies for tolerance induction that exploited natural mechanisms for clearing apoptotic debris, we show that antigen-decorated microparticles (500-nm diameter) induce long-term
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