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Merck
CN
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文件

695467

Sigma-Aldrich

1,3,5-三氮杂-7-磷杂三环[3.3.1.13.7]癸烷

97%

别名:

1,3,5-三氮杂-7-磷代金刚烷, NSC 266642, PTA

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About This Item

经验公式（希尔记法）:
C6H12N3P
CAS号:
53597-69-6
分子量:
157.15
MDL编号:
MFCD00154905
UNSPSC代码:
12352005
PubChem化学物质编号:
329761745
NACRES:
NA.22

质量水平

100

检测方案

97%

形式

solid

反应适用性

reagent type: ligand
reaction type: Hydroformylations
reagent type: ligand
reaction type: Hydrogenations
reagent type: ligand
reaction type: Morita-Baylis-Hillman Reactions
reagent type: ligand
reaction type: Sonogashira Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

mp

244-250 °C

官能团

phosphine

SMILES字符串

C1N2CN3CN1CP(C2)C3

InChI

1S/C6H12N3P/c1-7-2-9-3-8(1)5-10(4-7)6-9/h1-6H2

InChI key

FXXRPTKTLVHPAR-UHFFFAOYSA-N

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相关类别

一般描述

在空气中稳定的有机催化剂，可用于 Baylis-Hillman 转化

应用

  • The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics.：该研究通过差异凝胶电泳(DIGE)蛋白质组学研究钌化合物的抗转移作用。分析了钌络合物中的1,3,5-三氮杂-7-磷杂金刚烷及其生物作用，说明它的潜在抗癌性(Guidi et al., 2013)。
  • Synthesis, antimicrobial and antiproliferative activity of novel silver(I) tris(pyrazolyl)methanesulfonate and 1,3,5-triaza-7-phosphadamantane complexes.：该研究详述含有1,3,5-三氮杂-7-磷杂金刚烷的新型银络合物的合成，评估它们的抗菌和抗增殖活性，说明该化合物可用于生物医学领域(Pettinari et al., 2011)。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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William D J Tremlett et al.
Journal of inorganic biochemistry, 199, 110768-110768 (2019-07-30)
Organometallic compounds based on bioactive ligand systems have shown promising antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive ligands resulted in organometallic complexes with potent anticancer activity, but they lack aqueous solubility for further development. We report
Phillips, A. D.; Gonsalvi, L. et al.
Coordination Chemistry Reviews, 248, 955-955 (2004)
He, Z. et al
Advanced Synthesis & Catalysis, 368, 413-413 (2006)
Leila Tabrizi et al.
Dalton transactions (Cambridge, England : 2003), 48(2), 728-740 (2018-12-19)
The new cyclometalated ruthenium(ii) complex, [Ru(CCC-Nap)(Ibu)(PTA)] was designed and synthesized using ibuprofen (Ibu), 1,3,5-triaza-7-phosphaadamantane (PTA) and CCC-pincer containing naproxen moiety (CCC-Nap) as ligands. The compounds were fully characterized by elemental analysis, FT-IR, multinuclear (1H, 13C, and 31P) NMR spectroscopy, and
Christopher S Wilson et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(50), 11593-11603 (2020-06-11)
Dinuclear metallodrugs offer much potential in the development of novel anticancer chemotherapeutics as a result of the distinct interactions possible with bio-macromolecular targets and the unique biological activity that can result. Herein, we describe the development of isostructural homo-dinuclear OsII
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相关内容

Frost Group – Professor Product Portal

The Frost group has a longstanding interest in aqueous phase organometallic chemistry with an emphasis on water-soluble phosphine ligands. One focus of this research group has been centered on the chemistry of the neutral, air stable, and water-soluble heterocyclic phosphine 1,3,5-Triaza-7-phosphaadamantane (PTA). PTA is a small phosphine ligands with a cone angle of ~103°. PTA binds metal centers quite strongly and is electronically more donating than PPh3. Ruthenium complexes of PTA have exhibited impressive anticancer activity. A wide variety of transition metal complexes of PTA have been utilized as catalysts for reactions such as hydrogenation, C-C bond forming reactions, atom transfer radical addition, and nitrile hydration.

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