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Merck
CN
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文件

678740

Sigma-Aldrich

(A-taPhos)2PdCl2

别名:

Pd(amphos)Cl2, 双（二- 叔 -丁基（4-二甲氨基苯基）膦）二氯化钯 (II)

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About This Item

经验公式（希尔记法）:
C32H56Cl2N2P2Pd
CAS号:
887919-35-9
分子量:
708.07
MDL编号:
MFCD09265123
UNSPSC代码:
12161600
PubChem化学物质编号:
24885453
NACRES:
NA.22

形式

solid

质量水平

200

反应适用性

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

官能团

phosphine

SMILES字符串

Cl[Pd]Cl.CN(c1ccc(P(C(C)(C)C)C(C)(C)C)cc1)C.CN(c2ccc(P(C(C)(C)C)C(C)(C)C)cc2)C

InChI

1S/2C16H28NP.2ClH.Pd/c2*1-15(2,3)18(16(4,5)6)14-11-9-13(10-12-14)17(7)8;;;/h2*9-12H,1-8H3;2*1H;/q;;;;+2/p-2

InChI key

DWOZNANUEDYIOF-UHFFFAOYSA-L

相关类别

一般描述

二（二叔丁基（4-二甲氨基苯基）膦）二氯钯（II）是一种化学式为C32H56Cl2N2P2Pd的有机化合物。 它常被用作有机合成的催化剂。

对于小规模和高通量用途，产品为ChemBeads（927791）

应用

钯催化交叉偶联反应应用指南
二（二叔丁基（4-二甲氨基苯基）膦）二氯钯（II）可用作催化剂:

  • 通过氨钯诱导的Heck型反应，手性选择性构建吲哚-融合双环[3.2.1]-辛烷。
  • 通过Suzuki交叉偶联反应后的分子内缩合反应，从邻溴N-甲苯磺酰腙和2-氨基苯硼酸酯合成苯并咪唑衍生物
  • 通过邻卤苯醇和内炔环化pd催化合成茚酮。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Palladium-catalyzed annulation of alkynes with ortho-halide-containing benzyl alcohols in aqueous medium
Feng J, et al.
The Journal of Organic Chemistry, 79(21), 10561-10567 (2014)
Microwave assisted synthesis of phenanthridine derivatives via Suzuki coupling and condensation
Dende SK, et al.
Results in Chemistry, 3, 00149-00149 (2021)
Enantioselective Synthesis of Indole-Fused Bicyclo [3.2. 1] octanes via Palladium (II)-Catalyzed Cascade Reaction
Wang G, et al.
Organic Letters, 23(3) (2021)
Arkady Krasovskiy et al.
Journal of the American Chemical Society, 131(43), 15592-15593 (2009-10-16)
Mix in water, stir. That is all that is required in this new approach to sp(3)-sp(2) cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd(0) in the presence of zinc
Anil S Guram et al.
Organic letters, 8(9), 1787-1789 (2006-04-21)
[reaction: see text] New air-stable PdCl(2){P(t)Bu(2)(p-R-Ph)}(2) (R = H, NMe(2), CF(3),) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of

商品

An Introduction to A-Phos, its Applications and Advantages

Ligand used to prepare a palladium dichloride catalyst on treatment with PdCl2(COD). The catalyst effectively cross-couples aryl boronic acids with heteroaryl chlorides.

实验方案

Cross-Coupling Reactions in Water

TPGS-750-M surfactant enables various reactions in water at room temperature, enhancing efficiency and versatility in synthesis.

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