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Merck
CN
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文件

674702

Sigma-Aldrich

PEPPSI™-SIPr 催化剂

Umicore

别名:

(1,3-双(2,6-二异丙基苯基)咪唑亚基)(3-氯吡啶基)二氯化钯(II)

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About This Item

经验公式（希尔记法）:
C32H42Cl3N3Pd
CAS号:
927706-57-8
分子量:
681.47
UNSPSC代码:
12161600
PubChem化学物质编号:
24885231
NACRES:
NA.22

反应适用性

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst

质量水平

100

制造商/商品名称

Umicore

mp

229-230 °C

SMILES字符串

Cl[Pd]Cl.Clc1cccnc1.CC(C)c2cccc(C(C)C)c2N3[CH]N(CC3)c4c(cccc4C(C)C)C(C)C

InChI

1S/C27H39N2.C5H4ClN.2ClH.Pd/c1-18(2)22-11-9-12-23(19(3)4)26(22)28-15-16-29(17-28)27-24(20(5)6)13-10-14-25(27)21(7)8;6-5-2-1-3-7-4-5;;;/h9-14,17-21H,15-16H2,1-8H3;1-4H;2*1H;/q;;;;+2/p-2

InChI key

BWASJRFNPJXAGT-UHFFFAOYSA-L

相关类别

应用

钯催化交叉偶联反应应用指南
C-C 和 C-N 偶联反应催化剂。

法律信息

Umicore 产品

该产品及其制造或使用都是Umicore PMC所拥有或控制的一项或多项已公布或申请中的美国专利（和外国等同专利）的主题。通过Sigma-Aldrich、其附属公司或授权经销商购买来自Umicore PMC的本品赋予买方受限的、一次性、非排他性、不可转让、不可让渡的许可权。买方使用本产品可能侵犯第三方拥有或控制的专利。买方的唯一责任是确保产品的使用不会侵犯第三方的专利权或超出授权许可的范围。

如需有关产品的更多信息，请在http://www.pmc.umicore.com查看您当地的Umicore PMC联系信息

美国专利号7,250,510。由Total Synthesis Ltd独家授权销售。
PEPPSI is a trademark of Total Synthesis Ltd.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 + H312 + H332

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Organ, Michael G.; Abdel-Hadi, Mirvat; et al.
Chemistry (Weinheim An Der Bergstrasse, Germany), 12, 150-150 (2006)
Eric Assen B Kantchev et al.
Angewandte Chemie (International ed. in English), 46(16), 2768-2813 (2007-04-06)
Palladium-catalyzed C-C and C-N bond-forming reactions are among the most versatile and powerful synthetic methods. For the last 15 years, N-heterocyclic carbenes (NHCs) have enjoyed increasing popularity as ligands in Pd-mediated cross-coupling and related transformations because of their superior performance
Michael G Organ et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 14(8), 2443-2452 (2008-01-29)
Pd-N-heterocyclic carbene (NHC)-catalyzed Buchwald-Hartwig amination protocols mediated by Pd-PEPPSI precatalysts is described. These protocols provide access to a range of hindered and functionalized drug-like aryl amines in high yield with both electron-deficient and electron-rich aryl- and heteroaryl chlorides and bromides.

商品

PEPPSI™-IPent for Demanding Cross-Coupling Reactions

Professor Mike Organ and co-workers have developed the PEPPSI™ (Pyridine-Enhanced Precatalyst Preparation Stabilization and Initiation) precatalysts for palladium-catalyzed cross-coupling reactions.

PEPPSI™ Catalysts Overview

PEPPSI™ palladium N-heterocyclic-carbene catalyst system enhances efficiency and functional group tolerance in catalysis.

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