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包含
0.26-0.35 mmol/g phosphorous
0.37-0.44 mmol/g palladium
组成
Pd, 1.0
TPP, 0.8
反应适用性
core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
标记范围
0.4 mmol/g Pd loading
一般描述
It is an encapsulated catalyst (EnCat®), wherein palladium acetate and triphenylphosphine (TPP) are microencapsulated within a polyurea matrix, which prevents palladium leaching.
应用
可回收利用的负载化催化剂体系，在 C-C 键的形成和还原过程中可简化钯的除去。
Pd EnCat® TPP30 may be used as a catalyst for the microwave-assisted Sonogashira cross-coupling of:
- Aryl iodides and bromides with terminal alkynes to form the corresponding coupling products under copper-free conditions.
- Bromobenzotriazoles and arylacetylenes in the presence of 1,5-diazabicyclo[5.4.0]undecene-5-ene (DBU) and copper iodide to form 2H-benzo[d][1,2,3]triazole derivatives.
特点和优势
The advantages of using Pd EnCat® catalysts are:
- low residual metal levels in crude product
- easy recovery of catalyst
- compatibility of immobilized metal with various ligands to effect C-C bond forming reactions
- safer and easier to handle than Pd/C for hydrogenation
- efficiency and economy gains through recovery and recycling
其他说明
基质含量 30%
法律信息
PdEncat 技术已申请国际专利，包括 PCT/GB 02/03135。
EnCat is a registered trademark of Reaxa Ltd.
警示用语：
Warning
危险分类
Aquatic Chronic 3 - Carc. 2 - Flam. Sol. 2 - Repr. 2 - STOT RE 2 Oral
靶器官
Liver,Kidney
储存分类代码
4.1B - Flammable solid hazardous materials
WGK
WGK 3
闪点(°F)
-9.4 - -7.6 °F
闪点(°C)
-23 - -22 °C
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
易制毒化学品（2类）
Pd-EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl-and Alkenyl-Substituted Acetylenes via Microwave-Assisted Sonogashira Type Reactions.
Sedelmeier J, et al.
European Journal of Organic Chemistry, 2009(26), 4412-4420 (2009)
Self-assembly of T-shape 2H-benzo[d][1,2,3]-triazoles. Optical waveguide and photophysical properties.
Torres I, et al.
Royal Society of Chemistry Advances, 6(43), 36544-36553 (2016)
Yu, J.Q., et al.
Chemical Communications (Cambridge, England), 678-697 (2003)
Steven V Ley et al.
Chemical communications (Cambridge, England), (10), 1134-1135 (2002-07-19)
Palladium(II) acetate microencapsulated in polyurea (MC-[Pd]) is an economical and versatile heterogeneous catalyst for a range of phosphine-free cross-coupling reactions in both conventional solvents and supercritical carbon dioxide (scCO2); the catalyst can be recovered by a simple filtration and recycled
Steven V Ley et al.
Organic letters, 5(24), 4665-4668 (2003-11-25)
[reaction: see text] Pd nanoparticles (approximately 2 nm in size) microencapsulated in polyurea is an efficient and recyclable catalyst for reductive ring-opening hydrogenolysis of epoxides, using either HCOOH/Et(3)N or H(2) as a hydrogen donor.
相关内容
Homogeneous palladium catalysts are widely utilized due to their versatility, reactivity and functional group tolerance.
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