637505
(R)-(-)-3-氟吡咯烷盐酸盐
97%
别名:
(-)-3-Fluoropyrrolidine hydrochloride, (3R)-3-Fluoropyrrolidine hydrochloride, (R)-(-)-3-Fluoropyrrolidine hydrochloride, (R)-3-Fluoropyrrolidine hydrochloride, 3-(R)-Fluoropyrrolidine hydrochloride
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所有图片(1)
About This Item
经验公式（希尔记法）:
C4H9ClFN
CAS号:
分子量:
125.57
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
方案
97%
表单
solid
旋光性
[α]20/D -8.0°, c = 4 in methanol
mp
179-186 °C
官能团
fluoro
SMILES字符串
Cl.F[C@@H]1CCNC1
InChI
1S/C4H8FN.ClH/c5-4-1-2-6-3-4;/h4,6H,1-3H2;1H/t4-;/m1./s1
InChI key
LENYOXXELREKGZ-PGMHMLKASA-N
应用
(R)-(−)-3-Fluoropyrrolidine hydrochloride may be used as a substrate in the preparation of:
- Imidazo[1,2-a]pyrazine derivatives as possible aurora kinase inhibitors.
- Pyrazolopyrimidine derivatives as possible PDE10A Inhibitors.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Aurora kinase inhibitors based on the imidazo[1, 2-a] pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure
Kerekes AD, et al.
Journal of Medicinal Chemistry, 54(1), 201-210 (2011)
Discovery of a pyrazolo [1, 5-a] pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety
Koizumi Y, et al.
Bioorganic & Medicinal Chemistry, 27(15), 3440-3450 (2019)
Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units
Yamagami T, et al.
Organic Process Research & Development, 23(4), 578-587 (2019)
Charles G Caldwell et al.
Bioorganic & medicinal chemistry letters, 14(5), 1265-1268 (2004-02-26)
Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good
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