所有图片(1)
About This Item
线性分子式:
BrC6H3(F)NO2
CAS号:
分子量:
220.00
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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质量水平
方案
96%
折射率
n20/D 1.575 (lit.)
沸点
240-241 °C (lit.)
mp
18-19 °C (lit.)
密度
1.786 g/mL at 25 °C (lit.)
官能团
bromo
fluoro
nitro
SMILES字符串
[O-][N+](=O)c1cc(Br)ccc1F
InChI
1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
InChI key
UQEANKGXXSENNF-UHFFFAOYSA-N
一般描述
4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product.
应用
4-Bromo-1-fluoro-2-nitrobenzene may be used in the synthesis of:
- 6-bromo-1H-benzo[d][1,2,3]triazol-1-ol
- 2-(4-bromo-2-nitrophenylamino)-5-methylthiophene-3-carbonitrile
- dibenzoxazepine analog, as potent sodium channel blocker
- 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylic acid tert-butylester
Used in the synthesis of anti-inflammatory agents.
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
Katie M Lutker et al.
Crystal growth & design, 8(1), 136-139 (2008-01-01)
Bis(5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrilyl)acetylene, a derivative of the highly polymorphic compound 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) that possesses two chromophores electronically coupled through a triple bond, was found to be trimorphic. Structural data for two of these forms indicates that symmetry is maintained in one structure
Patrick L DeRoy et al.
Organic letters, 9(14), 2741-2743 (2007-06-08)
The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mild conditions.
Stephen M Lynch et al.
Bioorganic & medicinal chemistry letters, 25(1), 43-47 (2014-12-04)
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
Erik Rytter Ottosen et al.
Journal of medicinal chemistry, 46(26), 5651-5662 (2003-12-12)
We wish to report the synthesis and structure-activity relationship (SAR) of a series of 4-aminobenzophenones, as a novel compound class with high antiinflammatory activity. Our initial lead, (4-[(2-aminophenyl)amino]phenyl)(phenyl)methanone (3), was systematically optimized and resulted in compounds that potently inhibited the
Venkateshwarlu Gurram et al.
Advanced synthesis & catalysis, 357(2-3), 451-462 (2015-03-03)
Benzotriazoles are a highly important class of compounds with broad-ranging applications in such diverse areas as medicinal chemistry, as auxiliaries in organic synthesis, in metallurgical applications, in aircraft deicing and brake fluids, and as antifog agents in photography. Although there
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