质量水平
检测方案
97%
反应适用性
reaction type: click chemistry
折射率
n20/D 1.36 (lit.)
bp
153 °C (lit.)
密度
1.723 g/mL at 25 °C (lit.)
SMILES字符串
OC(=O)C(F)(F)S(F)(=O)=O
InChI
1S/C2HF3O4S/c3-2(4,1(6)7)10(5,8)9/h(H,6,7)
InChI key
VYDQUABHDFWIIX-UHFFFAOYSA-N
一般描述
2,2-二氟-2-(氟磺酰基)乙酸试剂可用作酚羟基二氟甲基化的二氟卡宾来源。
应用
2,2-二氟-2-(氟磺酰基)乙酸可被用于以下过程:
- 通过与相应的2-氯吡啶反应制备1-二氟甲基-2-氧代-1,2-二氢吡啶类似物。
- 制备作为新型高效二氟碳试剂的氟磺酰二氟乙酸硅酯用于烯烃的环丙烷化反应。
- 末端烯烃和炔烃与碘二氟甲烷磺酰胺的区域和立体选择性自由基氟烷基化反应。
警示用语:
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Skin Corr. 1A
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): a new, highly efficient difluorocarbene reagent
Journal of Fluorine Chemistry, 125, 459-469 (2004)
Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides
Science China: Chemistry, 54, 95-102 (2011)
Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides.
Science China: Chemistry, 54(1), 95-102 (2011)
Preparation and use of a new difluorocarbene reagent
Organic Syntheses, 80, 172-176 (2003)
Organic letters, 8(17), 3805-3808 (2006-08-11)
[reaction: see text] A novel one-pot synthesis of N-difluoromethyl-2-pyridones is described. N-(Pyridin-2-yl)acetamide derivatives were excellent precursors for the preparation of N-difluoromethyl-2-pyridone derivatives. Difluoromethylation of 2-acetaminopyridine derivatives was achieved with sodium chlorodifluoroacetate as a difluorocarbene source in the presence of a
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