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Merck
CN

525553

Sigma-Aldrich

4-苯基-1-(2H)-酞嗪酮

97%

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About This Item

经验公式(希尔记法):
C14H10N2O
CAS号:
分子量:
222.24
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

质量水平

方案

97%

mp

240-244 °C (lit.)

官能团

phenyl

SMILES字符串

O=C1NN=C(c2ccccc2)c3ccccc13

InChI

1S/C14H10N2O/c17-14-12-9-5-4-8-11(12)13(15-16-14)10-6-2-1-3-7-10/h1-9H,(H,16,17)

InChI key

XCJLBNVENUPHEA-UHFFFAOYSA-N

一般描述

4-Phenyl-1-(2H)-phthalazinone can be prepared from hydrazine sulphate and sodium hydroxide.

应用

4-Phenyl-1-(2H)-phthalazinone may be used in the synthesis of 2-chloro-N-(unsubstituted/substitutedphenyl) acetamide.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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Kazuko Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1326-1333 (2014-06-11)
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and
Wagdy M Eldehna et al.
European journal of medicinal chemistry, 89, 549-560 (2014-12-03)
A novel series of N-substituted-4-phenylphthalazin-1-ones 14a-g bearing different anilines at the N-2 of phthalazin-1-one scaffold via acetyl-flexible linker was designed and synthesized for the development of potential anticancer agents. Compounds 19a-g were synthesized by insertion of methylene (CH2) bridge at

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