检测方案
98%
折射率
n20/D 1.5170 (lit.)
bp
138 °C (lit.)
密度
1.039 g/mL at 25 °C (lit.)
SMILES字符串
Fc1cccc(c1)C#C
InChI
1S/C8H5F/c1-2-7-4-3-5-8(9)6-7/h1,3-6H
InChI key
PTRUTZFCVFUTMW-UHFFFAOYSA-N
警示用语:
Warning
危险分类
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
90.0 °F
闪点(°C)
32.2 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS).
Beilstein journal of organic chemistry, 5, 35-35 (2009-09-25)
Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors are flowed through these capillaries while the metal film is being heated
Chemistry (Weinheim an der Bergstrasse, Germany), 15(43), 11668-11674 (2009-09-25)
A simple and efficient method for the synthesis of gamma,delta-alkynyl-beta-amino acid derivatives by a copper-catalyzed three-component amine-alkyne-alkyne addition reaction was developed. Various gamma,delta-alkynyl-beta-amino acid derivatives were synthesized in moderate to good yields in one step. With chiral prolinol derivatives employed
Probe Reports from the NIH Molecular Libraries Program, 2011 Oct 31 (Updated 2013 Mar 7) (2013-06-14)
A series of acetylenic biaryl mGlu5 positive allosteric modulators (PAMs) have been optimized as pure potentiators in low receptor expressing mGlu5 cell lines. ML254 was identified and shown to competitively interact with the MPEP allosteric binding site. Preliminary data from
Probe Reports from the NIH Molecular Libraries Program, 2011 Dec 16 (Updated 2013 Mar 7) (2013-06-14)
Allosteric modulators for G-protein-coupled receptors (GPCRs) provide numerous advantages over orthosteric ligands, including greater sub-type selectivity, reduced receptor desensitization, saturability of effect, and potential for enhanced therapeutic index. Positive allosteric modulators (PAMs) of the group I metabotropic glutamate receptor mGlu
Angewandte Chemie (International ed. in English), 53(35), 9316-9320 (2014-07-22)
A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich
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