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Merck
CN
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文件

512125

Sigma-Aldrich

吡啶-3-硼酸

≥95.0%

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别名:
3-吡啶硼酸
经验公式（希尔记法）:
C5H6BNO2
CAS号:
1692-25-7
分子量:
122.92
MDL编号:
MFCD00674177
UNSPSC代码:
12352103
PubChem化学物质编号:
24873612
NACRES:
NA.22

质量水平

100

检测方案

≥95.0%

形式

solid

mp

>300 °C (lit.)

SMILES字符串

OB(O)c1cccnc1

InChI

1S/C5H6BNO2/c8-6(9)5-2-1-3-7-4-5/h1-4,8-9H

InChI key

ABMYEXAYWZJVOV-UHFFFAOYSA-N

相关类别

应用

3-吡啶基硼酸可用作以下反应中的试剂：
  • 不含磷的Suzuki-Miyaura交叉偶联反应
  • 区域选择性Suzuki-Miyaura偶联和串联钯催化的分子内氨基羰基化和环化
  • 乙酰丙酮铜催化的N-芳基化反应
  • 铜介导的富电子苯的氰化和区域选择性氰化反应

它也可用于制备：
  • 通过Suzuki偶联反应制备新型线性聚（苯基吡啶基）链
  • 低聚吡啶基折叠体，作为α-螺旋扭曲结构的模拟物
  • 许多非常重要的治疗性酶和激酶抑制剂以及受体拮抗剂
  • 通过Suzuki偶联反应与二溴吡啶胺化物反应生成吡啶取代的吡啶N-（2′-叠氮基）胺化物。

其他说明

含不定量的酸酐

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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The design and characterization of two, dual adenosine A(2A)/A(1) receptor antagonists in several animal models of Parkinson's disease is described. Compound 1 was previously reported as a potential treatment for Parkinson's disease. Further characterization of 1 revealed that it was
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Perato, S.; et al.
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