488712
(三氟甲基)三甲基硅烷
99%
别名:
(Trifluoromethyl)trimethylsilane, Ruppert 试剂, TFMTMS
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线性分子式:
(CH3)3SiCF3
化学文摘社编号:
分子量:
142.19
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4241868
产品名称
(三氟甲基)三甲基硅烷, 99%
InChI
1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
SMILES string
C[Si](C)(C)C(F)(F)F
InChI key
MWKJTNBSKNUMFN-UHFFFAOYSA-N
assay
99%
reaction suitability
reaction type: C-C Bond Formation
bp
54-55 °C (lit.)
density
0.962 g/mL at 20 °C (lit.)
functional group
fluoro
storage temp.
2-8°C
Quality Level
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Application
三甲基（三氟甲基）硅烷可以在以下过程中用作三氟甲基化剂：
- 将 N-(叔-丁基亚磺酰基）-亚胺转化为三氟甲基化胺
- 将反式-烯酮转化为反式-α-三氟甲基甲硅烷基醚
- 偶氮甲亚胺的三氟甲基化
- 将H-膦酸酯转化为CF3-膦酸酯
- 三氟甲基通过亲核加成转化成醛和酮。
signalword
Danger
hcodes
Hazard Classifications
Flam. Liq. 2 - Water-react 2
存储类别
4.3 - Hazardous materials which set free flammable gases upon contact with water
wgk
WGK 3
flash_point_f
1.4 °F - closed cup
flash_point_c
-17 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
Craig P Johnston et al.
Journal of the American Chemical Society, 140(35), 11112-11124 (2018-08-07)
The mechanism of CF3 transfer from R3SiCF3 (R = Me, Et, iPr) to ketones and aldehydes, initiated by M+X- (<0.004 to 10 mol %), has been investigated by analysis of kinetics (variable-ratio stopped-flow NMR and IR), 13C/2H KIEs, LFER, addition
Copper-catalyzed aerobic oxidative trifluoromethylation of H-phosphonates using trimethyl (trifluoromethyl) silane
Chu L, et al.
Synthesis, 44(10), 1521-1525 (2012)
CsF-catalyzed nucleophilic trifluoromethylation of trans-enones with trimethyl (trifluoromethyl) silane: A facile synthesis of trans-?-trifluoromethyl allylic alcohols.
Singh R P, et al.
Organic Letters, 1(7), 1047-1049 (1999)
Catalytic enantioselective trifluoromethylation of azomethine imines with trimethyl (trifluoromethyl) silane
Kawai H, et al.
Angewandte Chemie (International Edition in English), 121(34), 6442-6445 (2009)
Peter T Kaplan et al.
Beilstein journal of organic chemistry, 13, 2297-2303 (2017-11-29)
A number of copper reagents were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any bottlenecks, and provide more insight into the
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