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反应适用性
reaction type: Grignard Reaction
质量水平
浓度
0.5 M in THF
沸点
65-67 °C
密度
0.955 g/mL at 25 °C
SMILES字符串
COc1ccc([Mg]Br)cc1
InChI
1S/C7H7O.BrH.Mg/c1-8-7-5-3-2-4-6-7;;/h3-6H,1H3;1H;/q;;+1/p-1
InChI key
JKXAZEXIOPFJSC-UHFFFAOYSA-M
应用
4-甲氧基苯基溴化镁是一种通用的格氏试剂，可用于：
- 卟啉去炔化和用镁取代金属中心。
- 合成微管蛋白聚合抑制剂 2-氨基-3,4,5-三甲氧基二苯甲酮。
- （−）-centrolobine 的全合成。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
靶器官
Central nervous system, Respiratory system
补充剂危害
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
-4.0 °F
闪点(°C)
-20 °C
法规信息
危险化学品
Two successive one-pot reactions leading to the expeditious synthesis of (−)-centrolobine.
Boulard L, et al.
Tetrahedron Letters, 45(35), 6603-6605 (2004)
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Demetalation of Metal Porphyrins via Magnesium Porphyrins by Reaction with Grignard Reagents.
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