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质量水平
检测方案
95%
形式
solid
mp
158-161 °C (lit.)
SMILES字符串
Fc1cccc2C(=O)OC(=O)c12
InChI
1S/C8H3FO3/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3H
InChI key
WWJAZKZLSDRAIV-UHFFFAOYSA-N
一般描述
3-Fluorophthalic anhydride undergoes reduction with NaBH4 to afford 4-fluorophthalide and 7-fluorophthalide. It can be synthesized starting from 3-nitrophthaloyl dichloride.
应用
3-Fluorophthalic anhydride may be used in the preparation of substituted benzamides with potential neuroleptic activity. It may be employed as starting reagent for the synthesis of 8-fluoro-10-methyl-1,2-benzanthracene.
警示用语：
Warning
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Notes-Preparation of 3-Fluorophthalic Anhydride.
Heller A.
The Journal of Organic Chemistry, 25(5), 834-835 (1960)
Regioselectivity of metal hydride reductions of unsymmetrically substituted cyclic anhydrides. systems where" steric hindrance along the preferred reaction path" rationalization is not applicable.
Kayser MM and Morand P.
Canadian Journal of Chemistry, 58(23), 2484-2490 (1980)
Yingming Wang et al.
Colloids and surfaces. B, Biointerfaces, 188, 110795-110795 (2020-01-29)
Anaplastic lymphoma kinase (ALK) is a major target in treating non-small-cell lung cancer, and several ALK inhibitors have been developed to antagonize its kinase activity. However, patients treated with inhibitors ultimately develop drug resistance. Therefore, therapies with new mechanisms of
Synthesis of 8-Fluoro-10-methyl-1, 2-benzanthracene1.
Newman MS and Wiseman EH.
The Journal of Organic Chemistry, 26(9), 3208-3211 (1961)
A new synthesis of 3-fluorophthalic anhydride.
Passudetti M, et al.
Journal of Fluorine Chemistry, 50(2), 251-255 (1990)
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