等级
purum p.a.
质量水平
检测方案
≥98.0% (GC)
形式
liquid
折射率
n20/D 1.569 (lit.)
bp
178 °C/25 mmHg (lit.)
mp
25-27 °C (lit.)
密度
1.482 g/mL at 25 °C (lit.)
痕量阳离子
Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
K: ≤100 mg/kg
Na: ≤100 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg
储存温度
2-8°C
SMILES字符串
[O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O
InChI
1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChI key
LOTKRQAVGJMPNV-UHFFFAOYSA-N
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一般描述
1-氟-2,4-二硝基苯(FDNB,Sanger 试剂)用于鉴定氨基酸序列。这种化学物质用于标记蛋白质和多肽中的游离氨基。它也可用于保护胺基,并用于苯酚脱氧。此外,它在亲核取代反应中是一种非常有用的试剂,可引入胺、酚和硫醇的发色团。
应用
1-氟-2,4-二硝基苯用作衍生化剂:
- 氨基糖苷类化合物,如阿米卡辛、妥布霉素、庆大霉素、西西霉素、奈胺、新霉素 B 和新霉素 C。
- 研究在几种表面活性剂存在下与硫醇反应的动力学分析和分析用途。
警示用语:
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
327.2 °F
闪点(°C)
164 °C
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
危险化学品
Journal of chromatography. A, 883(1-2), 113-118 (2000-07-26)
A rapid and simple method is presented for determining neuro-excitatory nonprotein amino acid 3-N-oxalyl-2,3-diaminopropionic acid (beta-ODAP) and non-protein amino acids in Lathyrus sativus. Seed and foliage extracts of Lathyrus sativus were treated with 1-fluoro-2,4-dinitrobenzene (FDNB) and a reversed-phase high-performance liquid
Spectrophotometric determination of lisinopril in tablets using 1-fluoro-2,4-dinitrobenzene reagent.
Journal of pharmaceutical and biomedical analysis, 29(5), 865-872 (2002-07-03)
A spectrophotometric method for the determination of lisinopril (LN) in single and multicomponent tablets also containing hydrochlorothiazide (HCT), based on the derivatization reaction with 1-fluoro-2,4-dinitrobenzene (FDNB, Sanger reagent) is described. Aqueous solutions of LN (4.5-27.2 x 10(-5) M) react with
PloS one, 8(2), e57668-e57668 (2013-03-08)
The cholinergic anti-inflammatory system and α7 nicotinic receptors in macrophages have been proposed to play a role in neuroimmunomodulation and in the etiology of ulcerative colitis. We investigated the ability of a cholinesterase (ChE) inhibitor rivastigmine, to improve the pathology
The Journal of allergy and clinical immunology, 132(6), 1348-1357 (2013-08-21)
Innate immune sensors control key cytokines that regulate T-cell priming and T-cell fate. This is particularly evident in allergic reactions, which represent ideal systems to study the interplay of innate and adaptive immunity. In patients with contact dermatitis, inflammasome-mediated IL-1
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6476-6481 (2013-04-12)
B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor important for the differentiation and function of several types of immune cells. Because skin serves as a physical barrier and acts as an immune sentinel, we investigated whether Blimp-1 is involved
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