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质量水平
检测方案
97%
形式
solid
mp
74-77 °C (lit.)
溶解性
toluene: soluble 2.5%, clear, yellow
SMILES字符串
O=C1SSc2ccccc12
InChI
1S/C7H4OS2/c8-7-5-3-1-2-4-6(5)9-10-7/h1-4H
InChI key
GZTYTTPPCAXUHB-UHFFFAOYSA-N
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一般描述
3H-1,2-苯并二磺酚-3-酮是杂环合成砌块。
已有报道称3H-1,2-苯并二磺酚-3-酮可与三苯基膦反应生成二硫代水杨基内酯。
应用
3H-1,2-苯并二磺酚-3-酮（1,2-苯并二磺酚-3-酮）可用作硫转移剂，用于将H-膦硫代酸酯和H-膦酸酯二酯转化为相应的二硫代和单硫代磷酸酯。
在制备含硫代磷酸酯的寡脱氧核糖核苷酸时，可以使用3H-1,2-苯二硫基-3-酮作为硫化试剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Novel syntheses of dithiosalicylide.
Mitra K and Gates KS.
Tetrahedron Letters, 36(9), 1391-1394 (1995)
Q Xu et al.
Nucleic acids research, 24(9), 1602-1607 (1996-05-01)
Previous methods for the preparation of phosphorothioate-containing oligodeoxyribonucleotides rely on the reaction of phosphite triesters with sulfurizing reagents such as tetraethylthiuram disulfide (TETD) and 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage reagent). However, these and other sulfurizing reagents suffer from several disadvantages, and there
Nucleoside H-phosphonates. 13. Studies on 3H-1, 2-benzodithiol-3-one derivatives as sulfurizing reagents for H-phosphonate and H-phosphonothioate diesters.
Stawinski J and Thelin M.
The Journal of Organic Chemistry, 56(17), 5169-5175 (1991)
Santhosh Sivaramakrishnan et al.
Bioorganic & medicinal chemistry letters, 18(10), 3076-3080 (2007-12-11)
Though less potent than the parent natural product leinamycin, S-deoxyleinamycin displays activity against human cancer cell lines that is comparable to many clinically used agents. The results reported here suggest that the 1,2-dithiolan-3-one heterocycle found in S-deoxyleinamycin reacts with thiols
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