质量水平
检测方案
98%
mp
224-227 °C (lit.)
SMILES字符串
Fc1ccc2NC(=O)C(=O)c2c1
InChI
1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
InChI key
GKODDAXOSGGARJ-UHFFFAOYSA-N
一般描述
据报道,5-氟靛红是舒尼替尼(Sutent)药物的前体。2006年,美国食品药品监督管理局(FDA)批准5-氟靛红用于肾细胞癌(RCC)和胃肠道间质瘤(GIST)的治疗。
应用
5-氟靛红可用于:
- 作为基于反应的探针,通过19F磁共振波谱检测过氧亚硝酸盐中的活细胞
- 非侵入性检测干扰素-γ(IFN-γ)刺激的活肺上皮细胞中过氧亚硝酸盐(ONOO(-))的形成
- 在不使用任何有机溶剂或酸催化剂的情况下,通过与芳香伯双胺在水混悬介质中缩合合成双席夫碱
- 合成3-丙酮基-5-氟-3-羟基羟吲哚
作为反应物用于制备:
- 螺[吲哚-噻唑烷酮]作为生物合成支架的研究
- 潜在的抗分枝杆菌药物
- c-Met激酶抑制剂
- TAK1激酶抑制剂
- 单纯疱疹病毒抑制剂
- IKKβ 抑制剂
- 白癜风疾病抑制剂
- 具有抗HIV活性和抗结核活性的潜在候选药物
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Counter-Current chromatography separation of isatin derivatives using the sandmeyer methodology.
Journal of the Brazilian Chemical Society, 21(4), 764-769 (2010)
Chemical communications (Cambridge, England), 50(82), 12311-12314 (2014-09-03)
We report a newly discovered oxidative decarbonylation reaction of isatins that is selectively mediated by peroxynitrite (ONOO(-)) to provide anthranilic acid derivatives. We have harnessed this rapid and selective transformation to develop two reaction-based probes, 5-fluoroisatin and 6-fluoroisatin, for the
A Novel Preparation of a-Substituted Tryptamines from Isatins.
Journal of the Chemical Society, 2, 1335-1337 (1963)
Molecules (Basel, Switzerland), 11(1), 59-63 (2007-10-27)
Condensation of aromatic primary bis-amines with isatin (1H-indole-2,3-dione) and 5-flouroisatin occurred cleanly and efficiently in a water suspension medium without using any organic solvent or acid catalyst. The corresponding bis-Schiff bases were obtained in good yields and were easily isolated
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