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Merck
CN

346160

Sigma-Aldrich

乙炔基氯化镁 溶液

0.5 M in THF

别名:

Chloromagnesium acetylide

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About This Item

线性分子式:
CH≡CMgCl
CAS号:
分子量:
84.79
MDL编号:
UNSPSC代码:
12352103
PubChem化学物质编号:
NACRES:
NA.22

形式

liquid

质量水平

反应适用性

reaction type: Grignard Reaction

浓度

0.5 M in THF

密度

0.921 g/mL at 25 °C

储存温度

2-8°C

SMILES字符串

Cl[Mg]C#C

InChI

1S/C2H.ClH.Mg/c1-2;;/h1H;1H;/q;;+1/p-1

InChI key

YEWNLGTVYUADOR-UHFFFAOYSA-M

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应用

Ethynylmagnesium chloride solution can be used:
  • To synthesize 1-ethynyldeoxyribose derivatives which can further undergo Sonogashira coupling with various aryl, heteroaryl, and metallocenyl derivatives.
  • In one of the key synthetic steps of substituted naphthostyrils.
  • In the preparation of propargylic ester precursor for the synthesis of 1,3-dienylphosphonates.

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警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

靶器官

Central nervous system, Respiratory system

补充剂危害

储存分类代码

4.3 - Hazardous materials which set free flammable gases upon contact with water

WGK

WGK 3

闪点(°F)

-16.6 °F - closed cup

闪点(°C)

-27 °C - closed cup

法规信息

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A novel and convenient method for the synthesis of substituted naphthostyrils
Liu J, et al.
Tetrahedron Letters, 44(12), 2545-2548 (2003)
New and efficient synthesis of 1, 3-dienylphosphonates by Palladium-catalyzed substitution of propargylic esters to diethyl phosphite
Liu X, et al.
Synthetic Communications, 43(19), 2622-2626 (2013)
Sonogashira reactions of α-and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides
Bobula T, et al.
Tetrahedron, 66(2), 530-536 (2010)

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