所有图片(1)
别名:
p-Fluorophenylmagnesium bromide, Bromo(4-fluorophenyl)magnesium, Bromo(p-fluorophenyl)magnesium
线性分子式:
FC6H4MgBr
CAS号:
分子量:
199.30
Beilstein:
636802
MDL编号:
UNSPSC代码:
12352103
PubChem化学物质编号:
NACRES:
NA.22
推荐产品
质量水平
反应适用性
reaction type: Grignard Reaction
浓度
1.0 M in THF
密度
1.021 g/mL at 25 °C
SMILES字符串
Fc1ccc([Mg]Br)cc1
InChI
1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
InChI key
QYBFFRXNNFXREA-UHFFFAOYSA-M
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应用
4-氟苯基溴化镁溶液（格氏试剂）可用作合成以下化合物的试剂：
- 帕罗西汀合成中的关键中间体。
- 通过与硫醇的交叉偶联反应生成芳基硫化物。
- 作为雄激素受体拮抗剂的4-芳基甲基-1-苯基吡唑和4-芳氧基-1-苯基吡唑衍生物。
- 用于制备阿瑞吡坦的Grignard 中间体。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
靶器官
Respiratory system
补充剂危害
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
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R A Milius et al.
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Jun-Hao Cheng et al.
The Journal of organic chemistry, 77(22), 10369-10374 (2012-10-17)
A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were
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