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Merck
CN

180823

Sigma-Aldrich

5-甲基-5-苯基乙内酰脲

99%

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别名:
5-Methyl-5-phenylimidazolidine-2,4-dione, NSC 14839
经验公式(希尔记法):
C10H10N2O2
CAS号:
分子量:
190.20
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

检测方案

99%

mp

199-201 °C (lit.)

分离技术

chiral

SMILES字符串

CC1(NC(=O)NC1=O)c2ccccc2

InChI

1S/C10H10N2O2/c1-10(7-5-3-2-4-6-7)8(13)11-9(14)12-10/h2-6H,1H3,(H2,11,12,13,14)

InChI key

JNGWGQUYLVSFND-UHFFFAOYSA-N

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应用

Reactant for synthesis of:
Beta-amino alcohols as inhibitors of anti-tubercular target N-acetyltransferase
Chlorohydantoins
Specific MMP inhibitors

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Pirkle WH and Gan KZ.
Journal of Chromatography A, 790(1), 65-71 (1997)
Daniel C Whitehead et al.
Tetrahedron letters, 50(6), 656-658 (2010-02-17)
A simple and efficient methodology for the preparation of N-chlorinated hydantoins is presented. These versatile chlorenium sources were isolated in high yield after a simple recrystallization. Among the ten examples are the first chiral N-chlorohydantoins.
Elizabeth Fullam et al.
Bioorganic & medicinal chemistry letters, 21(4), 1185-1190 (2011-01-22)
The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.
B Chankvetadz et al.
Journal of pharmaceutical and biomedical analysis, 15(9-10), 1577-1584 (1997-06-01)
The techniques for a dynamic and permanent reversal of the electroosmotic flow (EOF) were used for the reversal of the enantiomer migration order (EMO) of neutral and cationic analytes in chiral capillary electrophoresis (CE). Native beta-Cd and an anionic CD
Adriana Bakalova et al.
European journal of medicinal chemistry, 38(6), 627-632 (2003-07-02)
The interaction of cis-dichlorodiaminplatinum(II) (cis-DDP) with 2,4-imidazolidenedione-5-methyl-5-phenyl was studied. The method of preparation of the new Pt(II) complex consisted in precipitation of chloride ions from cis-DDP via a diaqua complex and reaction with the ligand in water-organic media. On the

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