Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.

Bioorganic & medicinal chemistry letters (2011-01-22)

Elizabeth Fullam, Areej Abuhammad, David L Wilson, Matthew C Anderton, Steve G Davies, Angela J Russell, Edith Sim

摘要

The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.