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Key Documents

Safety Information

SAB4500366

Sigma-Aldrich

Anti-Collagen Type II (COL2A1) Antibody

rabbit polyclonal

Synonym(s):

CO2A1, chondrocalcin, collagen, collagen α-1 (II), type II

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43
To inquire about this product SAB4500366, please contact your local Merck office or dealer. Contact Technical Service

Product Name

Anti-Collagen II antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 141 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

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随机引物 DNA 标记试剂盒

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form

liquid

form

solution

form

suspension

form

-

usage

0.1 mL sufficient for 100 RT-PCR reactions

usage

0.1 mL sufficient for 100 RT-PCR reactions (as described in the Technical Bulletin for Product Codes HSRT100 and HSRT20)

usage

-

usage

sufficient for 50 labeling reactions

concentration

50 μM in H2O

concentration

70 μM in H2O

concentration

-

concentration

-

shipped in

wet ice

shipped in

wet ice

shipped in

-

shipped in

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

General description

Anti-Collagen II Antibody detects endogenous levels of total Collagen II protein.
Collagen type II α 1 chain (COL2A1) gene is mapped to human chromosome 12q13.11–q13.12. COL2A1 belongs to collagen superfamily. The encoded protein is characterized with three identical α chains forming homotrimers. Collagen II is the major component of cartilage.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen II.

Immunogen Range: 101-150

Application

Anti-Collagen II, N-Terminal antibody produced in rabbit has been used for:
  • Western blotting[1]
  • Immunofluorescence
  • Immunohistological analyses[2]
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (2 papers)

Biochem/physiol Actions

Mutation of collagen type II α 1 chain (COL2A1), leads to a variety of clinical manifestations such as skeletal dysplasia, short stature, and sensorial defects, collectively known as type II collagenopathies. Function of COL2A1 in articular cartilage is to form highly organized fibers, which are essential for the mechanical properties of the tissue.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    310155

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    Shiping Shi et al.
    Experimental and therapeutic medicine, 24(2), 526-526 (2022-07-16)
    Osteoarthritis (OA) is a chronic condition caused by cartilage degradation, and there are currently no effective methods for preventing the progression of this disease; gene therapy is a relatively novel method for treating arthritis. Decreased collagen type II (Col2) expression
    E V Isaeva et al.
    Sovremennye tekhnologii v meditsine, 15(2), 5-16 (2023-06-30)
    The aim of the study was to compare type I collagen-based and methacryloyl gelatin-based (GelMA) hydrogels by their ability to form hyaline cartilage in animals after subcutaneous implantation of scaffolds. Chondrocytes were isolated from the costal cartilage of newborn rats
    Elena V Isaeva et al.
    International journal of molecular sciences, 23(5) (2022-03-11)
    The aim of this study was to verify the applicability of high-concentration collagen-based bioink with MSC (ADSC) and decellularized ECM granules for the formation of cartilage tissue de novo after subcutaneous implantation of the scaffolds in rats. The printability of
    Guokun Chen et al.
    Frontiers in pharmacology, 11, 527744-527744 (2020-10-13)
    The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene
    Mouna Barat-Houari et al.
    Human mutation, 37(1), 7-15 (2015-10-08)
    Mutations in the COL2A1 gene cause a spectrum of rare autosomal-dominant conditions characterized by skeletal dysplasia, short stature, and sensorial defects. An early diagnosis is critical to providing relevant patient care and follow-up, and genetic counseling to affected families. There
    View All Related Papers

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