SAB4500362
Anti-Collagen I antibody produced in rabbit
affinity isolated antibody
Synonym(s):
α 2 type i collagen, co1a2, col1a2, collagen, type i
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1 G
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1 G
CN¥1,434.82
5 G
CN¥5,020.05
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
CN¥1,434.82
Please contact Customer Service for Availability
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 129 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
1 of 4
This Item | OGS624 | OGS620 | OGS628 |
|---|---|---|---|
| bacteria selection ampicillin | bacteria selection ampicillin | bacteria selection ampicillin | bacteria selection ampicillin |
| peptide cleavage EKT | peptide cleavage EKT | peptide cleavage EKT | peptide cleavage EKT |
| peptide tag location C-terminal | peptide tag location N-terminal | peptide tag location N-terminal | peptide tag location C-terminal |
| origin of replication pUC | origin of replication pUC | origin of replication pUC | origin of replication pUC |
| mol wt size 5897 bp | mol wt size 5913 bp | mol wt size 4568 bp | mol wt size 5923 bp |
General description
Collagen I is encoded by the gene COL1A2 (collagen type I alpha 2). The gene is located on human chromosome 7q21.3. COL1A2 is a fibril forming collagen, found in bone, dermis, tendon, ligaments and cornea.
Collagen is the major structural component of extracellular matrices found in connective tissues and internal organs, but is most prevalent in the dermis, tendons, and bones. It is classified into a number of structurally and genetically distinct types. Type I collagen is a heterodimer composed of two α1(I) chains and one α2(I) chain that spontaneously forms a triple helix scaffold at neutral pH and 37 °C. Collagen type I is an excellent substrate for the culture of hepatocytes, fibroblasts, spinal ganglion, muscle cells, Schwann cells, embryonic lung cells, epithelial cells, and a number of other cell lines. It has also been used in the study of growth, differentiation, migration of cell lines, and tissue morphogenesis during development.
Rabbit polyclonal anti-Collagen I, N-Terminal antibody reacts with mouse, rat, and human type I collagens.
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen I.
Immunogen Range: 1-50
Immunogen Range: 1-50
Application
Anti-Collagen I antibody produced in rabbit has been used in western blotting and immunostaining.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Rabbit polyclonal anti-Collagen I, N-Terminal antibody is used to tag collagen type I for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of collagen type I as a cell substrate.
Biochem/physiol Actions
Collagen I interacts with cytoskeleton and regulates cell motility. Mutations in this gene is linked to osteoporotic fracture, osteogenesis imperfecta and recessive classical type Ehlers-Danlos syndrome. It is also associated with idiopathic osteoporosis and atypical Marfan syndrome.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Lina Wang et al.
Molecular medicine reports, 16(1), 310-316 (2017-05-13)
Emerging evidence has demonstrated that endoplasmic reticulum stress (ER) is involved in the pathogenesis of idiopathic pulmonary fibrosis, however, the underlying mechanism remains unclear. Viral infection often triggers a hyperinflammatory response by an expansion of the ER. The present study
Nastaran Tarban et al.
Cells, 11(8) (2022-04-24)
Skeletal muscle repair is initiated by local inflammation and involves the engulfment of dead cells (efferocytosis) by infiltrating macrophages at the injury site. Macrophages orchestrate the whole repair program, and efferocytosis is a key event not only for cell clearance
Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration
Tuinstra HM, et al.
Tissue Engineering: Part A, 20(5-6), 1027-1037 (2013)
The importance of polymorphic variants of collagen 1A2 gene (COL1A2) in the development of osteopenia and osteoporosis in postmenopausal women
Majchrzycki M, et al.
Ginekologia Polska, 88(8), 414-420 (2017)
COL1A2 is a Novel Biomarker to Improve Clinical Prediction in Human Gastric Cancer: Integrating Bioinformatics and Meta-Analysis
Rong L, et al.
Pathology Oncology Research, 24(1), 129-134 (2018)
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