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SAB4200678

Sigma-Aldrich

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

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Synonym(s):
Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

300

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

COL-1, monoclonal

form

buffered aqueous solution

species reactivity

pig, rat, human, deer, bovine

concentration

~1 mg/mL

technique(s)

ELISA: suitable
dot blot: suitable
immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum
immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL1A1(1277)

General description

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.
Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogen

bovine skin collagen type I

Application

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Biochem/physiol Actions

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.
Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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Gao Q, et al.
Oncotarget, 8(55), 93899-93899 (2017)
Overexpression of CXCR4 promotes invasion and migration of non?small cell lung cancer via EGFR and MMP?9.
Zuo J, et al.
Oncology Letters, 14(6), 7513-7521 (2017)
Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera.
Zhou X, et al.
Molecular Vision, 18, 1312-1312 (2012)
Identification of Broadly Applicable Adeno-Associated Virus Vectors by Systematic Comparison of Commonly Used Capsid Variants In Vitro.
Weinmann, et al.
Human Gene Therapy, 33, 1197-1212 (2023)
Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome.
Malfait F, et al.
Orphanet Journal of Rare Diseases, 8(1), 78-78 (2013)
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