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E7138

Sigma-Aldrich

Ethosuximide

Synonym(s):

2-Ethyl-2-methylsuccinimide

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0.5 ML
CN¥2,240.04
1 ML
CN¥4,144.31

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0.5 ML
CN¥2,240.04
1 ML
CN¥4,144.31

About This Item

Empirical Formula (Hill Notation):
C7H11NO2
CAS Number:
77-67-8
Molecular Weight:
141.17
EC Number:
201-048-7
MDL number:
MFCD00072123
UNSPSC Code:
12352111
PubChem Substance ID:
24278423
NACRES:
NA.77

CN¥2,240.04

Please contact Customer Service for Availability
New, lower price on this item!
Request a Bulk Order

Quality Level

100

solubility

ethanol: 100 mg/mL

SMILES string

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Gene Information

human ... CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911)

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HNDG4MAG36K

MILLIPLEX® Human Neurodegenerative Disease Magnetic Bead Panel 4 - Neuroscience Multiplex Assay

MILLIPLEX® Human Neuroscience Magnetic Bead Panel 1 - Neuroscience Multiplex Assay allows quantitative multiplex detection of multiple analytes simultaneously

HNS1MAG95K

MILLIPLEX® Human Neuroscience Magnetic Bead Panel 1 - Neuroscience Multiplex Assay

MILLIPLEX® Human Neurological Disorders Magnetic Bead Panel 3 - Neuroscience Multiplex Assay The analytes available for this multiplex kit are: AGT, Contactin-1, Fetuin A, Kallikrein-6, OPN, sSOD1, sSOD2

HND3MAG39K

MILLIPLEX® Human Neurological Disorders Magnetic Bead Panel 3 - Neuroscience Multiplex Assay

MILLIPLEX® Human Neurodegenerative Disease Magnetic Bead Panel 3 - Neuroscience Multiplex Assay The analytes available for this multiplex kit are: BDNF, Cathepsin D, MPO, NCAM, PAI-1 (total), PDGF-AA, PDGF-AB/BB, RANTES, sICAM-1, sVCAM-1.

HNDG3MAG36K

MILLIPLEX® Human Neurodegenerative Disease Magnetic Bead Panel 3 - Neuroscience Multiplex Assay

assay range

accuracy: 84-108%, standard curve range: 21-15,000 pg/mL
(sRAGE), standard curve range: 3-2,500 pg/mL
(Amyloid β40), standard curve range: 27-20,000 pg/mL
(Amyloid β42), standard curve range: 14-10,000 pg/mL
(S100B), standard curve range: 7-5,000 pg/mL
(GDNF)

assay range

accuracy: 107%
(DJ1), accuracy: 108%
(a-Synuclein), accuracy: 123%
(TG2), standard curve range: 12-50,000 pg/mL
(GFAP), standard curve range: 15-60,000 pg/mL
(NSE), standard curve range: 20-80,000 pg/mL
(UCHL1), standard curve range: 244-1,000,000 pg/mL
(alpha-synuclein), standard curve range: 61-250,000 pg/mL
(DJ1), standard curve range: 61-250,000 pg/mL
(TG2)

assay range

accuracy: 69-92%
(Cerebrospinal fluid (CSF)), accuracy: 71-107%
(Serum), standard curve range: 0.03-25 ng/mL
(SOD2), standard curve range: 0.04-30 ng/mL
(Kallikrein-6), standard curve range: 0.04-30 ng/mL
(SOD1), standard curve range: 0.08-60 ng/mL
(Contactin-1), standard curve range: 0.14-100 ng/mL
(Osteopontin (OPN)), standard curve range: 1.37-1,000 ng/mL
(AGT), standard curve range: 4.12-3,000 ng/mL
(Fetuin A)

assay range

accuracy: 108%
(RANTES), accuracy: 108%
(sICAM-1), accuracy: 111%
(Cathepsin D), accuracy: 123%
(PDGF-AA), accuracy: 137%
(PDGF-AB/BB), standard curve range: 2-10,000 pg/mL
(RANTES), standard curve range: 2.4-10,000 pg/mL
(BDNF), standard curve range: 2.4-10,000 pg/mL
(PAI-1 (total)), standard curve range: 2.4-10,000 pg/mL
(PDGF-AA), standard curve range: 24-100,000 pg/mL
(Cathepsin D), standard curve range: 24-100,000 pg/mL
(MPO), standard curve range: 24-100,000 pg/mL
(NCAM), standard curve range: 24-100,000 pg/mL
(PDGF-AB/BB), standard curve range: 24-100,000 pg/mL
(sICAM-1), standard curve range: 61-250,000 pg/mL
(sVCAM-1)

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

manufacturer/tradename

Milliplex®

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

detection method

fluorometric (Luminex xMAP)

Application

Ethosuximide has been used:
  • to confirm its effect on spike wave discharges (SWD) in rats[1]
  • to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type[2]
  • as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug[3] and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.[1]

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    MKCJ7744
    MKCH8509
    MKCG7467

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    Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo
    Huang HY, et al.
    Journal of Materials Chemistry, 22(17), 8566-8573 (2012)
    Emilio Russo et al.
    Epilepsia, 52(7), 1341-1350 (2011-06-04)
    Depression is most commonly associated with epilepsy. Recent reports have suggested a putative relationship between seizure development and onset of depressive behavior, whereas others proposed that two clinical entities might represent different neuropathologic aspects of the same neurologic disorder. The
    Gabi Dezsi et al.
    Epilepsia, 54(4), 635-643 (2013-03-08)
    Ethosuximide (ESX) is a drug of choice for the symptomatic treatment of absence seizures. Chronic treatment with ESX has been reported to have disease-modifying antiepileptogenic activity in the WAG/Rij rat model of genetic generalized epilepsy (GGE) with absence seizures. Here
    Gilles van Luijtelaar et al.
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 85(1), 49-54 (2011-09-29)
    Recently it was established that early long lasting treatment with the anti-absence drug ethosuximide (ETX) delays the occurrence of absences and reduces depressive-like symptoms in a genetic model for absence epilepsy, rats of the WAG/Rij strain. Here it is investigated
    Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
    Pearce PS, et al.
    Epilepsy & Behavior : E&B, 32, 121-131 (2014)
    View All Related Papers

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