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Merck
CN

T2528

Terbutaline hemisulfate salt

β-adrenoceptor agonist

Synonym(s):

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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About This Item

Linear Formula:
C12H19NO3 · 1/2H2SO4
CAS Number:
23031-32-5
Molecular Weight:
274.32
NACRES:
NA.77
PubChem Substance ID:
24278729
UNSPSC Code:
12352200
EC Number:
245-386-3
MDL number:
MFCD00079584

Key Documents

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Product Name

Terbutaline hemisulfate salt,

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

SMILES string

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

solubility

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

originator

Novartis

Quality Level

100

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

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Application

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

Biochem/physiol Actions

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

Features and Benefits

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H361,H370

Hazard Classifications

Repr. 2 - STOT SE 1

target_organs

Cardio-vascular system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4064
BCCJ7739
BCCC7481
BCBV3715
BCBQ7406V

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Md Faiyazuddin et al.
International journal of pharmaceutics, 434(1-2), 59-69 (2012-05-16)
Terbutaline submicron particles (SμTBS) were prepared by nanoprecipitation technique followed by spray drying for deep lungs deposition. Inhalable SμTBS particles were 645.16 nm of diameter with 0.11μm of MMAD, suggested for better aerosol effects. Both submicron and micron-sized TBS particles
Andrew H Travers et al.
The Cochrane database of systematic reviews, 12, CD010179-CD010179 (2012-12-14)
Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents. To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma
K Törneke et al.
Journal of veterinary pharmacology and therapeutics, 21(5), 388-392 (1998-11-12)
Beta2-adrenoceptor agonists are used as bronchodilators in both humans and horses. Of these drugs, clenbuterol is the one most frequently used when treating chronic obstructive pulmonary disease in the horse, while salbutamol and terbutaline are used in the treatment of
J Elers et al.
International journal of sports medicine, 33(12), 1026-1033 (2012-07-12)
We examined urine and serum concentrations after therapeutic use of single and repetitive doses of inhaled and supratherapeutic oral use of terbutaline. We compared the concentrations in 10 asthmatics and 10 healthy subjects in an open-label, cross-over study with 2
Zbys Fedorowicz et al.
The Cochrane database of systematic reviews, 5(5), CD008585-CD008585 (2012-05-18)
Dysmenorrhoea is a common gynaecological complaint that can affect as many as 50% of premenopausal women, 10% of whom suffer severely enough to be rendered incapacitated for one to three days during each menstrual cycle. Primary dysmenorrhoea is where women
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