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I7378

Sigma-Aldrich

Indomethacin

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

Synonym(s):

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

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100 ML
CN¥439.40

CN¥439.40

Estimated to ship onJune 23, 2025Details

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100 ML
CN¥439.40

About This Item

Empirical Formula (Hill Notation):
C19H16ClNO4
CAS Number:
53-86-1
Molecular Weight:
357.79
Beilstein:
497341
EC Number:
200-186-5
MDL number:
MFCD00057095
UNSPSC Code:
12161501
PubChem Substance ID:
24278173
NACRES:
NA.77

CN¥439.40

Estimated to ship onJune 23, 2025Details

Request a Bulk Order

Product Name

Indomethacin, 98.5-100.5% (in accordance with EP)

biological source

synthetic

Quality Level

200

Assay

98.5-100.5% (in accordance with EP)

form

powder or crystals

loss

≤0.5% loss on drying

mp

158-162 °C

Mode of action

enzyme | inhibits

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

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1 of 4

This Item
I8280PHR1247405268
Indomethacin 98.5-100.5% (in accordance with EP)

I7378

Indomethacin

Indomethacin meets USP testing specifications

I8280

Indomethacin

Indomethacin Pharmaceutical Secondary Standard; Certified Reference Material

PHR1247

Indomethacin

Indomethacin A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.

405268

Indomethacin

assay

98.5-100.5% (in accordance with EP)

assay

98.0-102.0%

assay

-

assay

≥98% (by assay)

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

100

biological source

synthetic

biological source

-

biological source

-

biological source

-

loss

≤0.5% loss on drying

loss

-

loss

-

loss

-

mp

158-162 °C

mp

-

mp

-

mp

-

General description

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome.[1] Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.[2]

Application

Indomethacin has been used:
  • as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells[3]
  • as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture[4]
  • in the inhibition of prostaglandin E2 (PGE2) in T cells[5]

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 1 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000419112
    0000419111
    0000419112
    0000419111
    0000410675

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    A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus
    Van Overmeire B, et al.
    The New England Journal of Medicine, 343(10), 674-681 (2000)
    Therapeutic potential of amniotic fluid stem cells to treat bilateral ovarian dystrophy in dairy cows in a subtropical region
    Chang LB, et al.
    Reproduction in domestic animals = Zuchthygiene, 53(2), 433-441 (2018)
    Effectiveness of the use of Rectal Indometacin in the prevention of post-CPRE pancreatitis in the Naval Medical Center.
    Islava EE, et al.
    INTERNATIONAL JOURNAL OF ADVANCED MULTIDISCIPLINARY RESEARCH, 5(11), 44-51 (2018)
    Suppression of T cells by mesenchymal and cardiac progenitor cells is partly mediated via extracellular vesicles
    van den Akker F, et al.
    Heliyon, 4(6), e00642-e00642 (2018)
    Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells
    Kolhe R, et al.
    Nutrients, 10(2), 186-186 (2018)
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