HNDG3MAG-36K

MILLIPLEX^® Human Neurodegenerative Disease Panel

Name: MILLIPLEX<SUP>®</SUP> Human Neurodegenerative Disease Panel
Brand: MM

Configurable Human Neurodegenerative Disease 10-Plex Panel 3

Synonym(s):

Human NeuroscienceProtein MultiplexAssay, Luminex^® Human Neuroscience Panel, Millipore Human Neuroscience Immunoassay

About This Item

UNSPSC Code:

12161503

NACRES:

NA.84

eCl@ss:

32161000

Key Documents

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Product Name

MILLIPLEX^® Human Neurodegenerative Disease Panel, Configurable Human Neurodegenerative Disease 10-Plex Panel 3

species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex^®

assay range

accuracy: 108%
(RANTES)
accuracy: 108%
(sICAM-1)
accuracy: 111%
(Cathepsin D)
accuracy: 123%
(PDGF-AA)
accuracy: 137%
(PDGF-AB/BB)
standard curve range: 2-10,000 pg/mL
(RANTES)
standard curve range: 2.4-10,000 pg/mL
(BDNF)
standard curve range: 2.4-10,000 pg/mL
(PAI-1 (total))
standard curve range: 2.4-10,000 pg/mL
(PDGF-AA)
standard curve range: 24-100,000 pg/mL
(Cathepsin D)
standard curve range: 24-100,000 pg/mL
(MPO)
standard curve range: 24-100,000 pg/mL
(NCAM)
standard curve range: 24-100,000 pg/mL
(PDGF-AB/BB)
standard curve range: 24-100,000 pg/mL
(sICAM-1)
standard curve range: 61-250,000 pg/mL
(sVCAM-1)

technique(s)

multiplexing: suitable

input

cell culture supernatant
cerebrospinal fluid(s) (CSF)
serum

detection method

fluorometric (Luminex^® xMAP^® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 10 analytes in human serum, plasma, and cerebrospinal fluid (CSF).Analytes included: BDNF, Cathepsin D, sICAM-1, MPO, PDGF-AA, RANTES, NCAM, PDGF-AB/BB, sVCAM-1, PAI-1(total).Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Mutiplex Discovery Power: Simultaneously quantify a diverse array of biomarkers from neurotrophic factors to inflammatory mediators, providing unprecedented breadth of neurobiological insight in a single multiplex assay.Configurable Panel Flexibility: Design your ideal research solution by selecting any combination of the 10 available analytes to create a configured kit that perfectly matches your specific research objectives and hypotheses.All-in-One Convenience: Receive complete assurance with our comprehensive box format containing all necessary reagents, eliminating procurement delays and ensuring seamless experimental execution from start to finish.Cross-Matrix Compatibility: Analyze serum, plasma, and cerebrospinal fluid samples with validated performance, maximizing sample utility and enabling comprehensive biomarker profiling across diverse biological specimens.

General description

Neurodegeneration often reflects a breakdown in cellular communication and vascular health. BDNF, a vital neurotrophic factor, underpins neuronal survival and adaptability, with diminished levels tied to Alzheimer′s and stroke. Vascular adhesion molecules sICAM-1 and sVCAM-1 reveal inflammation and blood-brain barrier compromise. PDGF isoforms promote vascular repair and neuronal resilience, while immune markers like RANTES, MPO, and cathepsin D highlight ongoing tissue damage and immune activation.

pictograms

GHS08,GHS05,GHS07,GHS09

signalword

Danger

hcodes

H302 + H312 + H332,H315,H317,H318,H373,H411

pcodes

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

新产品

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Inter-relation between brain-derived neurotrophic factor and antioxidant enzymes in bipolar disorder.

Rodrigo B Mansur et al.

Bipolar disorders, 18(5), 433-439 (2016-08-05)

Accumulating evidence indicates that oxidative stress and neurotrophins have a bidirectional relationship. In this post hoc, exploratory analysis, we investigated the association between plasma brain-derived neurotrophic factor (BDNF) levels and activities of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF.

Luís F Martins et al.

Scientific reports, 7(1), 4153-4153 (2017-06-25)

Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low

Serum Platelet-Derived Growth Factor Is Significantly Lower in Patients with Lung Cancer and Continued to Decrease After Platinum-Based Chemotherapy.

Rong Ma et al.

OncoTargets and therapy, 13, 1883-1892 (2020-03-19)

This study aimed to investigate the diagnosis and prediction of serum platelet-derived growth factor (PDGF) level in patients with lung cancer (LC). Serum concentrations of PDGF-AA and PDGF-AB/BB were determined via Luminex assay in 210 patients with non-small cell lung

Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression.

Lyudmila A Levchuk et al.

Frontiers in psychiatry, 11, 296-296 (2020-05-07)

Alcohol Use Disorder (AUD) and depressive disorder often co-exist and have a shared heritability. This study aimed to investigate Brain-Derived Neurotrophic Factor (BDNF) and three Cell Adhesion Molecules (CAMs) as transdiagnostic biomarkers in AUD and depression co-morbidity. In a cross-sectional

Early CSF Biomarkers and Late Functional Outcomes in Spinal Cord Injury. A Pilot Study.

Rita Capirossi et al.

International journal of molecular sciences, 21(23) (2020-12-03)

Although, biomarkers are regarded as an important tool for monitoring injury severity and treatment efficacy, and for predicting clinical evolution in many neurological diseases and disorders including spinal cord injury, there is still a lack of reliable biomarkers for the

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MILLIPLEX^® Human Neurodegenerative Disease Panel