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Key Documents

29311

Sigma-Aldrich

CHES

BioUltra, ≥99.5% (T)

Synonym(s):

2-(Cyclohexylamino)ethanesulfonic acid

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50 MG
CN¥1,606.86

About This Item

Empirical Formula (Hill Notation):
C8H17NO3S
CAS Number:
Molecular Weight:
207.29
Beilstein:
2967601
EC Number:
MDL number:
UNSPSC Code:
12161700
PubChem Substance ID:
NACRES:
NA.25

CN¥1,606.86


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product line

BioUltra

Assay

≥99.5% (T)

form

powder

impurities

insoluble matter, passes filter test

ign. residue

≤0.05%

loss

≤0.5% loss on drying, 110 °C

pH

3.0-5.0 (25 °C, 0.5 M in H2O)

useful pH range

8.6-10.0

pKa (25 °C)

9.3

solubility

H2O: 0.5 M at 20 °C, clear, colorless

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1 of 4

This Item
SAB2702141HPA001334SAB4501753
biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

-

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

-

UniProt accession no.

P49916

UniProt accession no.

P49916

UniProt accession no.

P49917

UniProt accession no.

P18858

Gene Information

human ... LIG3(3980)

Gene Information

human ... LIG3(3980)

Gene Information

human ... LIG4(3981)

Gene Information

human ... LIG1(3978)

General description

Cyclohexylaminoethanesulfonic acid (CHES) is a buffering agent. Its structure contains a hydrophilic taurine (2-aminoethanesulfonic acid) moiety and a hydrophobic cyclohexyl group. CHES binds to the active site of several enzymes and inhibits substrate binding and enzymatic activity. Therefore, CHES may be used as a scaffold for new drug development for regulating enzyme activity.[1]

Application

2-(Cyclohexylamino)ethanesulfonic acid (CHES) has been used in the preparation of dimethyl trisulfide- polysorbate 80 (DMTS-PS80) formulation.[2]

Other Notes

Buffer for studying pH-dependent processes in enzymology;citation Has a high affinity for the iodoacetate binding site of liver alcohol dehydrogenase.citation
Buffer for studying pH-dependent processes in enzymology;[3] Has a high affinity for the iodoacetate binding site of liver alcohol dehydrogenase.[4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Craig M Bartling et al.
    Drugs in R&D, 16(1), 109-127 (2016-02-11)
    Novel cyanide countermeasures are needed for cases of a mass-exposure cyanide emergency. A lead candidate compound is dimethyl trisulfide (DMTS), which acts as a sulfur donor for rhodanese, thereby assisting the conversion of cyanide into thiocyanate. DMTS is a safe
    C Syvertsen et al.
    European journal of biochemistry, 117(1), 165-170 (1981-06-01)
    Both iodoacetic acid and (R,S)-2-bromo-3-(5-imidazolyl)propionic acid (BrImPpOH) react with liver alcohol dehydrogenase in an affinity labelling mechanism between pH 6.1 and 10.5. The buffer-independent dissociation constants and the first-order rate constants have been determined as a function of pH. With
    Youngjin Lee et al.
    Biochemical and biophysical research communications, 486(2), 470-475 (2017-03-21)
    Anti-bacterial and anti-viral neuraminidase agents inhibit neuraminidase activity catalyzing the hydrolysis of terminal N-acetylneuraminic acid (Neu5Ac) from glycoconjugates and help to prevent the host pathogenesis that lead to fatal infectious diseases including influenza, bacteremia, sepsis, and cholera. Emerging antibiotic and
    Jun Yang et al.
    Langmuir : the ACS journal of surfaces and colloids, 24(18), 10265-10272 (2008-08-20)
    A universal nitric oxide (NO) generating surface is assembled via Layer-by-Layer (LbL) deposition of sodium alginate (Alg) and organoselenium modified polyethyleneimine (SePEI) on quartz and polymeric substrates. The immobilized SePEI species is capable of catalytically decomposing S-nitrosothiol species (RSNO) to
    Buffers of constant ionic strength for studying pH-dependent processes.
    K J Ellis et al.
    Methods in enzymology, 87, 405-426 (1982-01-01)

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