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主要文件

安全信息

SAB3500929

Sigma-Aldrich

Anti-RIFT VALLEY FEVER VIRUS antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

virus

浓度

1 mg/mL

技术

ELISA: suitable

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

一般描述

Rift valley fever virus (RVFV) is an enveloped RNA virus belonging to the Phlebovirus genus of the family Bunyaviridae. RVFV possesses a single stranded segmented RNA genome composed of a large (L), a medium (M), and a small (S) segment. The L segment codes for the RNA-dependent RNA polymerase. The M segment codes for a polyprotein which is the precursor to the glycoproteins G1 and G2 and two non-structural proteins, 14K and 78K. The S segment codes for the nucleoprotein N and the non-structural protein NSs.

免疫原

Antibody was raised against a 20 amino acid synthetic peptide near the center of the RVF virus.

生化/生理作用

Rift valley fever virus (RVFV) causes rift valley fever (RVF), an arthropod-borne viral disease. The virus is transmitted either by an arthropod or direct transmission by contact or aerosol among the hosts. The non-structural phosphoprotein (NSs) is responsible for the virulence in the pathogenic RVFV and suppresses human interferon gene expression. The fever is mainly observed in sheep and cattle. In humans, RVF clinical symptoms includes benign fever to severe encephalitis, retinitis, and fatal hepatitis with haemorrhagic fever. RVFV may block α/β interferon (IFN-α/β) expression in host and may target transcription factor aswell TFIIH.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

联系

The action of this antibody can be blocked using blocking peptide SBP3500929.

外形

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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访问文档库

Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development
Caplen H, et al.
The Journal of General Virology, 66, 2271-2277 (1985)
Genetic evidence for an interferon-antagonistic function of rift valley fever virus non-structural protein NSs
Bouloy M, et al.
Journal of Virology, 75(3), 1371-1377 (2001)
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription
Billecocq A, et al.
Journal of Virology, 78(18), 9798-9806 (2004)

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