biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC39A8(64116)
General description
溶质载体家族39成员8(SLC39A8),也称为锌和铁相关蛋白8(ZIP8),是一种质膜转运蛋白。它是溶质载体基因超家族的一部分。编码SLC39A8的基因位于人染色体4q24上。
Immunogen
ZIP8抗体通过靶向人ZIP8的羧基末端附近的18个氨基酸多肽获得。
Application
兔抗ZIP8抗体可用于免疫细胞化学。
Biochem/physiol Actions
溶质载体家族39成员8(SLC39A8)共转运二价金属阳离子,例如镉,锌,锰和铁。它在细胞摄取镉中起着至关重要的作用。该蛋白是核因子κB(NF-κB)的靶标,并在促炎反应中起作用。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。
Physical form
以含有0.02%叠氮化钠的PBS形式提供。
Other Notes
可以使用阻断肽 SBP3500598阻断该抗体的作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity.
Zhang R
Human Molecular Genetics (2016)
ZIP8 regulates host defense through zinc-mediated inhibition of NF-?B.
Liu MJ
Cell Reports (2013)
Cellular localization and developmental
changes of Zip8, Zip14 and transferrin
receptor 1 in the inner ear of rats
changes of Zip8, Zip14 and transferrin
receptor 1 in the inner ear of rats
Dalian Ding
Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, And Medicine (2014)
Advances in the genetics of schizophrenia: toward a network and pathway view for drug discovery: Advances in the genetics of schizophrenia
David A
The New York State Dental Journal (2016)
Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8.
Boycott KM
American Journal of Human Genetics (2015)
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