推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 220 kDa
种属反应性
human
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ARHGEF17(9828)
一般描述
Rho guanine nucleotide exchange factor 17 (ARHGEF17), also known as tumor endothelial marker 4 (TEM4) and p164-RhoGEF (Rho-specific guanine-nucleotide exchange factor), encodes a guanine nucleotide exchange factor (GEF) for RhoA GTPases. The encoded protein consists of 1510 amino acids and contains a RhoGEF-specific Dbl homology (DH) domain. It does not contain the typical pleckstrin homology domain. TEM4 is predominantly expressed in the heart. Overexpression of this protein inhibits the transcription of M3 muscarinic receptor-induced genes. TEM4 modulates endothelial cell migration.
免疫原
TEM4 antibody was raised against a 18 amino acid peptide near the center of human TEM4.
特点和优势
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联系
The action of this antibody can be blocked using blocking peptide SBP3500457.
外形
Supplied in PBS with 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain
Ulrich Rumenapp
BioChemistry: An Indian Journal (2002)
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility.
Mitin N
PLoS ONE (2013)
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