Anti-MDA5 antibody produced in rabbit

Melanoma differentiation-associated protein 5 (MDA5), also known as interferon induced with helicase C domain 1 (IFIH1), is a cytosolic RNA sensor. It is encoded by the gene mapped to human chromosome 2q24.2. The encoded protein is a member of the retinoic acid-inducible gene I-like receptor family. MDA5 is characterized with both caspase recruitment domain and putative DExH group RNA helicase domains.

MDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.

Anti-MDA5 antibody produced in rabbit has been used in western blot analysis.

Melanoma differentiation-associated protein 5 (MDA5) plays a vital role in antiviral innate immune responses. In addition, the encoded protein also activates interferon regulatory factors 3 and 7 and nuclear factor-κB (NF-κB) via a mitochondrial viral signaling protein, inducing antiviral and proapoptotic responses, which is associated with various autoimmune diseases, such as type 1 diabetes (T1D), Graves′ disease (GD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA). Polymorphism in the gene is associated with the development of generalized vitiligo (GV).

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The action of this antibody can be blocked using blocking peptide SBP3500356.

Supplied in PBS with 0.02% sodium azide.

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