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PRS2447

Sigma-Aldrich

Anti-MTBP antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

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250 MG
¥1,245.18
1 G
¥3,260.71
5 G
¥10,782.06
25 G
¥22,395.62

¥1,245.18

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250 MG
¥1,245.18
1 G
¥3,260.71
5 G
¥10,782.06
25 G
¥22,395.62

About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

¥1,245.18

有货详情

生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

predicted mol wt 104 kDa

种属反应性

human

技术

immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

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application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

form

solid

form

solid

form

powder

form

solid

composition

Dye, ≥60% spectrophotometric assay

composition

Dye, ≥60% spectrophotometric assay

composition

Dye content, ≥60%

composition

Dye, ≥50% spectrophotometric assay

εmax

≥1500 at 623-628 nm in 50% ethanol at 0.005 g/L

εmax

-

εmax

-

εmax

≥810 at 630-635 nm in water at 0.005 g/L

Quality Level

400

Quality Level

200

Quality Level

200

Quality Level

400

免疫原

a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.

生化/生理作用

The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.

联系

The action of this antibody can be blocked using blocking peptide SBP2447.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide

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说明
价格

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    24470201
    2447-0201

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    Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization.
    Boyd MT
    Cytogenetics and Cell Genetics, 90, 64-65 (2000)
    MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.
    Grieb BC
    Molecular Cancer Research, 12, 1216-1224 (2014)
    MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.
    Lu S
    Digestive Diseases and Sciences, 60, 3681-3690 (2015)

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