推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 104 kDa
种属反应性
human
技术
immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MTBP(27085)
免疫原
a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.
生化/生理作用
The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.
联系
The action of this antibody can be blocked using blocking peptide SBP2447.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization.
Boyd MT
Cytogenetics and Cell Genetics, 90, 64-65 (2000)
MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.
Grieb BC
Molecular Cancer Research, 12, 1216-1224 (2014)
MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.
Lu S
Digestive Diseases and Sciences, 60, 3681-3690 (2015)
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