HPA024638
Anti-LAMC2 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-CSF 140 kDa subunit, Anti-Cell-scattering factor 140 kDa subunit, Anti-Kalinin/nicein/epiligrin 100 kDa subunit, Anti-Ladsin 140 kDa subunit, Anti-Laminin 5 gamma 2 subunit, Anti-Laminin B2t chain, Anti-Laminin subunit gamma-2
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所有图片(1)
About This Item
UNSPSC代码:
12352203
人类蛋白质图谱编号:
推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
产品线
Prestige Antibodies® Powered by Atlas Antibodies
表单
buffered aqueous glycerol solution
种属反应性
human
技术
immunohistochemistry: 1:1000- 1:2500
免疫原序列
NAGVTIQDTLNTLDGLLHLMDQPLSVDEEGLVLLEQKLSRAKTQINSQLRPMMSELEERARQQRGHLHLLETSIDGILADVKNLEN
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... LAMC2(3918)
一般描述
The gene LAMC2 (laminin subunit γ 2) is mapped to human chromosome 1q25-q31. LAMC2 is part of the heterotrimeric glycoprotein laminin-332.
免疫原
Laminin subunit gamma-2 Precursor recombinant protein epitope signature tag (PrEST)
应用
Anti-LAMC2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
In many tissues, LAMC2 (laminin subunit γ 2) acts as a structural component of the epithelial basement membrane. LAMC2 monomer is associated with cancers, such as lung adenocarcinoma, esophageal squamous cell carcinoma and pancreatic cancer. Mutations in LAMC2 are linked with junctional epidermolysis bullosa.
特点和优势
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
联系
Corresponding Antigen APREST76502.
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer.
D Korbakis et al.
British journal of cancer, 113(3), 484-491 (2015-07-17)
Non-small cell lung cancer (NSCLC) lacks reliable serological biomarkers for predicting patients' survival and response to treatment. The present study examined the capability of serum LAMC2 and four known tumour markers for disease prognosis and patients' risk stratification. LAMC2, CA
Hagen Klett et al.
Frontiers in genetics, 9, 108-108 (2018-04-21)
Late diagnosis and systemic dissemination essentially contribute to the invariably poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Therefore, the development of diagnostic biomarkers for PDAC are urgently needed to improve patient stratification and outcome in the clinic. By studying the
Joana Caldeira et al.
Human molecular genetics, 24(20), 5891-5900 (2015-08-08)
Epithelial-cadherin (Ecad) deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas. In gastric cancer, loss of Ecad expression is a common event and is associated with disease aggressiveness and poor prognosis. However, the molecular mechanisms underlying
Y W Moon et al.
Cell death and differentiation, 22(8), 1341-1352 (2015-01-17)
Lung cancer is the number one cancer killer, and metastasis is the main cause of high mortality in lung cancer patients. However, mechanisms underlying the development of lung cancer metastasis remain unknown. Using genome-wide transcriptional analysis in an experimental metastasis
Olivier Govaere et al.
The Journal of pathology, 248(1), 66-76 (2018-12-26)
Ductular reaction (DR) represents the activation of hepatic progenitor cells (HPCs) and has been associated with features of advanced chronic liver disease; yet it is not clear whether these cells contribute to disease progression and how the composition of their
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