LAMC2
laminin, gamma 2
别名:
B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
物种:
Human LAMC2 (3918), Mouse Lamc2 (16782), Rat Lamc2 (192362), domestic guinea pig Lamc2 (100733999), naked mole-rat Lamc2 (101719910), Horse LAMC2 (791245), cow LAMC2 (511043), sheep LAMC2 (100216328), chicken LAMC2 (408043), domestic cat LAMC2 (101089571)
UniProtKB ID:
基因ID:
- Human(3918) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]
- Mouse(16782) laminin, gamma 2
- Rat(192362) laminin, gamma 2
- domestic guinea pig(100733999) laminin, gamma 2
- naked mole-rat(101719910) laminin, gamma 2
- Horse(791245) laminin, gamma 2
- cow(511043) laminin, gamma 2
- sheep(100216328) laminin, gamma 2
- chicken(408043) laminin, gamma 2
- domestic cat(101089571) laminin, gamma 2
- dog(442939) laminin, gamma 2
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Antibodies
货号
说明
物种反应性
应用
抗层粘连蛋白-5（γ2链）抗体，克隆D4B5, clone D4B5, Chemicon®, from mouse,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Laminin-5 Antibody (γ2 chain), clone D4B5, Alexa Fluor™ 647 Conjugate, clone D4B5, from mouse, ALEXA FLUOR™ 647,
物种反应性
human, mouse
应用
immunocytochemistry
抗层粘连蛋白-5抗体，克隆P3E4, clone P3E4, Chemicon®, from mouse,
物种反应性
human
应用
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor™ 488 conjugated, clone D4B5, Chemicon®, from mouse,
物种反应性
human
应用
flow cytometry
immunocytochemistry
immunocytochemistry
Monoclonal Anti-LAMC2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL2980, purified immunoglobulin, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
货号
说明
物种
层粘连蛋白 来源于 Engelbreth-Holm-Swarm 小鼠肉瘤基底膜, 1-2 mg/mL in Tris-buffered saline, 0.2 μm filtered, BioReagent, suitable for cell culture,
物种
mouse
ECM 凝胶 来源于 Engelbreth-Holm-Swarm 小鼠肉瘤, growth-factor reduced, without phenol red, liquid, BioReagent, suitable for cell culture,
物种
mouse
esiRNA
货号
说明
物种