HPA008784

抗-FUS 兔抗

Name: 抗-FUS 兔抗
Brand: SIGMA

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-ALS6, 抗-FUS1, 抗-HNRNPP2, 抗-TLS, 抗-hnRNP-P2

登录查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

Human Protein Atlas Number:

HPA008784

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC

Citations:

主要文件

查看所有文档

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

mouse, rat, human

enhanced validation

RNAi knockdown
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:1000-1:2500

immunogen sequence

SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR

UniProt accession no.

P35637

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FUS(2521)

General description

FUS（在肉瘤中融合）是一种DNA/RNA结合蛋白，其C端包含一个核定位序列。富含谷氨酰胺-甘氨酸-丝氨酸-酪氨酸的区域位于其N端，在该蛋白的自组装中起重要作用。它最初是作为一种融合蛋白在脂肪肉瘤中发现的。

Immunogen

FUS RNA结合蛋白

Application

兔抗FUS抗体属 Prestige 抗体，经人类蛋白质图谱（HPA）计划开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接，可以在人类蛋白质图谱（HPA）站点上查看这些图像。还采用免疫荧光和蛋白质印迹法对抗体进行检测。想要查看有关Prestige 抗体和HPA的方案和其他实用信息，请访问 sigma.com/prestige。

Biochem/physiol Actions

FUS（融合肉瘤）基因突变会引发家族性肌萎缩侧索硬化症（ALS）。这种疾病是由于FUS细胞核定位序列突变聚集，FUS聚集体在细胞质中积聚。这种蛋白质是多功能的，在RNA代谢中发挥多种作用。在脂肪肉瘤中，该蛋白质的N端与CHOP（CCAAT增强子结合蛋白同源蛋白）转录因子的N端融合，激活致癌基因，引发肿瘤。这种蛋白质与神经退行性疾病的发病机制有关，其失活影响细胞的稳态。该蛋白质的失活会导致组蛋白H3磷酸化水平升高，从而导致细胞停滞，进一步影响细胞增殖。

Features and Benefits

Prestige抗体^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性^®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige Antibody都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige Antibody都是按照以下方法进行测试的：

44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
364个人类重组蛋白片段的蛋白阵列。

Physical form

溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠

Other Notes

对应抗原APREST86697

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

未找到合适的产品？

试试我们的产品选型工具.

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

低风险生物材料

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.

Clement T Loy et al.

Brain : a journal of neurology, 133(Pt 12), e158-e158 (2010-08-10)

Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.

Dhruva Deshpande et al.

Frontiers in cellular neuroscience, 13, 256-256 (2019-06-28)

Mutations in the fused in Sarcoma (FUS) gene induce cytoplasmic FUS aggregations, contributing to the neurodegenerative disease amyotrophic lateral sclerosis (ALS) in certain cases. While FUS is mainly a nuclear protein involved in transcriptional processes with limited cytoplasmic functions, it

New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.

Leone Chare et al.

Journal of neurology, neurosurgery, and psychiatry, 85(8), 865-870 (2014-01-15)

To assess the impact of new clinical diagnostic criteria for frontotemporal dementia (FTD) syndromes, including primary progressive aphasias (PPA), on prior clinical diagnosis and to explore clinicopathological correlations. 178 consecutive neuropathologically ascertained cases initially diagnosed with a FTD syndrome were

Self-assembled FUS binds active chromatin and regulates gene transcription.

Liuqing Yang et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(50), 17809-17814 (2014-12-03)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Fused in sarcoma (FUS) is a DNA/RNA binding protein and mutations in FUS cause a subset of familial ALS. Most ALS mutations are clustered in the C-terminal nuclear localization sequence of

Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.

Ito Kawakami et al.

Acta neuropathologica communications, 4, 36-36 (2016-04-06)

Choreoathetoid involuntary movements are rarely reported in patients with frontotemporal lobar degeneration (FTLD), suggesting their exclusion as a supportive feature in clinical diagnostic criteria for FTLD. Here, we identified three cases of the behavioral variant of frontotemporal dementia (bvFTD) that

查看所有相关文献

抗-FUS 兔抗

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

选择尺寸

关于此项目

主要文件

属性

biological source

conjugate

antibody form

antibody product type

clone

product line

form

species reactivity

enhanced validation

technique(s)

immunogen sequence

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

General description

Immunogen

Application

Biochem/physiol Actions

Features and Benefits

Physical form

Other Notes

Legal Information

Disclaimer

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

已有该产品？

同行评审论文

技术文章和实验方案

相关内容

技术服务

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution