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Merck
CN

POLR2A

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

别名:
POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
物种:
UniProtKB ID:
基因ID:
  • Human(5430) Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Mouse(20020) polymerase (RNA) II (DNA directed) polypeptide A
  • Rat(363633) polymerase (RNA) II (DNA directed) polypeptide A
  • cow(282312) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • naked mole-rat(101725588) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • dog(479483) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • Zebrafish(553347) polymerase (RNA) II (DNA directed) polypeptide A
  • sheep(100144762) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic cat(101098500) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic guinea pig(100734232) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

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Antibodies

货号
说明
物种反应性
应用
Anti-RNA Polymerase II Antibody, CTD Antibody, clone 8WG16, clone 8WG16, from mouse,
物种反应性
human, yeast
应用
dot blot
immunoprecipitation (IP)

inhibition assay

western blot
Anti-phospho RNA Pol II (Ser5), clone 1H4B6 Antibody, clone 1H4B6, from rat,
物种反应性
canine, human, monkey, mouse, rat
应用
ChIP
ELISA

immunocytochemistry

western blot
Monoclonal Anti-phospho-RNA polymerase II CTD (pSer2) antibody produced in rat, clone 3E7C7, purified from hybridoma cell culture,
物种反应性
应用
flow cytometry
immunofluorescence

western blot
抗磷酸化RNA Pol II(Ser2),克隆3E7C7抗体, clone 3E7C7, from rat,
物种反应性
canine, human, monkey, mouse, rat
应用
ChIP
ELISA

immunocytochemistry

western blot
Anti-POLR2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence

Proteins

货号
说明
物种
RNA聚合酶II,C端域,GST标记 人, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
物种
human
RNA Polymerase II, C-terminal human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human POLR2A,
物种
human
MISSION® esiRNA, targeting mouse Polr2a,
物种
mouse