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PDK1

pyruvate dehydrogenase kinase, isozyme 1

别名:
物种:
UniProtKB ID:
基因ID:
  • Human(5163) Summary: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
  • Mouse(228026) pyruvate dehydrogenase kinase, isoenzyme 1
  • Rat(116551) pyruvate dehydrogenase kinase, isozyme 1
  • fruit fly(38017) Phosphoinositide-dependent kinase 1
  • Zebrafish(555840) pyruvate dehydrogenase kinase, isozyme 1
  • Thale Cress(830330) 3'-phosphoinositide-dependent protein kinase 1
  • Horse(100064091) pyruvate dehydrogenase kinase, isozyme 1
  • domestic guinea pig(100715937) pyruvate dehydrogenase kinase, isozyme 1
  • naked mole-rat(101705587) pyruvate dehydrogenase kinase, isozyme 1
  • sheep(101113205) pyruvate dehydrogenase kinase, isozyme 1
  • Domestic Rabbit(100351323) pyruvate dehydrogenase kinase, isozyme 1
  • cow(528655) pyruvate dehydrogenase kinase, isozyme 1
  • domestic cat(101092705) pyruvate dehydrogenase kinase, isozyme 1
  • dog(476828) pyruvate dehydrogenase kinase, isozyme 1
  • chicken(425972) pyruvate dehydrogenase kinase, isozyme 1

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Small Molecule - Activator

货号
说明
物种
二氯乙酸, ReagentPlus®, ≥99%,
物种
human, rat

Antibodies

货号
说明
物种反应性
应用
Anti-PDK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-PDH kinase 1 Antibody, clone 1C7-H1 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
affinity binding assay
flow cytometry

immunocytochemistry

immunohistochemistry

western blot
Anti-PDK1/PDHK1 Antibody, clone 5T6S8, Rabbit Monoclonal, ,
物种反应性
human, rat
应用
immunohistochemistry
western blot
Monoclonal Anti-PDK1 antibody produced in mouse, clone 3E1, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
Anti-PDK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence

Small Molecule - Inhibitor

货号
说明
物种
二氯乙酸, ReagentPlus®, ≥99%,
物种
human, rat
二氯乙酸钠, 98%,
物种
human

Proteins

货号
说明
物种
PDHK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human PDK1,
物种
human
MISSION® esiRNA, targeting mouse Pdk1,
物种
mouse